GATIBAC
Generic Name
Gatifloxacin ophthalmic solution
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| gatibac 03 eye drop | ৳ 100.00 | N/A |
Description
Overview of the medicine
Gatifloxacin 0.3% eye drop is a fluoroquinolone antibiotic used to treat bacterial infections of the eye, such as bacterial conjunctivitis.
Uses & Indications
Dosage
Adults
Instill 1 drop into the affected eye(s) every 2 hours while awake, up to 8 times a day on Day 1. On Day 2-7, instill 1 drop into the affected eye(s) 2-4 times a day while awake.
Elderly
Same as adults.
Renal_impairment
No dosage adjustment needed for ophthalmic use.
How to Take
For ophthalmic use only. Tilt head back, pull lower eyelid down to form a pouch. Squeeze a drop into the pouch. Do not touch the dropper tip to the eye or any surface. Close eye gently for 1-2 minutes.
Mechanism of Action
Gatifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, essential enzymes for bacterial DNA replication, transcription, repair, and recombination. This leads to bacterial cell death.
Pharmacokinetics
Onset
Rapid, usually within hours of initial dose.
Excretion
Primarily renal for systemically absorbed drug, but very little is systemically absorbed.
Half life
Systemic half-life is around 7-14 hours, but local ocular half-life is not well characterized but drug remains in ocular tissues for sufficient time.
Absorption
Minimal systemic absorption following topical ocular administration. Primarily acts locally.
Metabolism
Minimal systemic metabolism for ophthalmic use.
Side Effects
Contraindications
- Hypersensitivity to gatifloxacin, other quinolones, or any component of the medication.
Drug Interactions
Other topical ophthalmic medications
If using multiple eye medications, administer them at least 5-10 minutes apart.
Storage
Store at room temperature (below 30°C), protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Unlikely with ophthalmic administration. In case of accidental ingestion or excessive ocular application, flush the eye with lukewarm water. Symptomatic and supportive measures may be necessary for accidental ingestion.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution advised during lactation as it is unknown if gatifloxacin is excreted in human milk.
Side Effects
Contraindications
- Hypersensitivity to gatifloxacin, other quinolones, or any component of the medication.
Drug Interactions
Other topical ophthalmic medications
If using multiple eye medications, administer them at least 5-10 minutes apart.
Storage
Store at room temperature (below 30°C), protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Unlikely with ophthalmic administration. In case of accidental ingestion or excessive ocular application, flush the eye with lukewarm water. Symptomatic and supportive measures may be necessary for accidental ingestion.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution advised during lactation as it is unknown if gatifloxacin is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 24-36 months (unopened), 28 days after opening.
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent
Clinical Trials
Efficacy and safety established in clinical trials for bacterial conjunctivitis.
Lab Monitoring
- Not typically required for ophthalmic gatifloxacin.
Doctor Notes
- Prescribe appropriately.
- Advise patients on proper instillation technique and completion of treatment course.
Patient Guidelines
- Complete the full course of treatment even if symptoms improve.
- Do not wear contact lenses during treatment for bacterial conjunctivitis.
- Avoid touching the dropper tip to prevent contamination.
- If irritation persists or worsens, consult a doctor.
Missed Dose Advice
If a dose is missed, apply it as soon as remembered. If it is almost time for the next dose, skip the missed dose and continue with the regular schedule. Do not double the dose.
Driving Precautions
May cause temporary blurred vision or discomfort after instillation. Avoid driving or operating machinery until vision is clear.
Lifestyle Advice
- Maintain good eye hygiene.
- Avoid sharing eye drops or towels.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.