Generic Ben-A Cream
Generic Name
Ben-A
Manufacturer
Generic Pharma Ltd.
Country
Bangladesh
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Description
Overview of the medicine
Ben-A is a topical corticosteroid preparation, typically containing Betamethasone Valerate. It is used to relieve inflammation, itching, and discomfort of various skin conditions such as eczema, psoriasis, and dermatitis. It works by reducing the body's immune response to these conditions.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected skin area once or twice daily. Do not use for more than 4 weeks without medical review.
Elderly
Use with caution. Similar dosage as adults, but monitor for systemic effects due to potentially thinner skin and comorbidities.
Renal_impairment
No specific dose adjustment required for topical application, but caution advised with extensive use due to minimal systemic absorption.
How to Take
For external use only. Apply thinly and gently rub into the affected area. Wash hands before and after application. Avoid contact with eyes, mouth, and other mucous membranes.
Mechanism of Action
Betamethasone, a corticosteroid, acts by inducing phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid.
Pharmacokinetics
Onset
Relief of symptoms typically within a few days of application.
Excretion
Excreted mainly via urine as metabolites; small amounts excreted in bile.
Half life
Not well defined for topical application due to minimal systemic absorption.
Absorption
Minimal systemic absorption through intact skin; absorption increases with skin damage, occlusion, or application to large areas.
Metabolism
Metabolized primarily in the liver, similar to systemic corticosteroids, but the extent is minimal with topical use.
Side Effects
Contraindications
- •Hypersensitivity to betamethasone or any component
- •Untreated cutaneous infections (viral, fungal, bacterial)
- •Rosacea
- •Acne vulgaris
- •Perioral dermatitis
- •Pruritus without inflammation
Drug Interactions
CYP3A4 Inhibitors
Although systemic absorption is minimal, potent CYP3A4 inhibitors (e.g., ritonavir, itraconazole) could theoretically increase systemic exposure if significant absorption occurs.
Systemic Corticosteroids
Concurrent use with systemic corticosteroids may increase the risk of systemic adverse effects, especially with extensive or prolonged use.
Storage
Store below 30°C. Protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is unlikely with topical application. Chronic overdose or misuse may lead to systemic effects such as Cushing's syndrome, adrenal suppression. Treatment is symptomatic and supportive; gradual withdrawal of the steroid may be necessary.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Topical corticosteroids should not be used extensively, in large amounts, or for prolonged periods in pregnant or lactating women. Consult a doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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