Glazide
Generic Name
Gliclazide
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| glazide 80 mg tablet | ৳ 6.00 | ৳ 60.00 |
Description
Overview of the medicine
Gliclazide is an oral antidiabetic drug used to control high blood sugar levels in people with type 2 diabetes mellitus. It belongs to the sulfonylurea class of drugs.
Uses & Indications
Dosage
Adults
Initially 40-80 mg once daily, usually before breakfast. Dose can be adjusted up to 320 mg/day in divided doses.
Elderly
Similar to adult dosage, but caution with initial dosing and titration to avoid hypoglycemia.
Renal_impairment
No significant dose adjustment for mild to moderate impairment; use with caution in severe renal impairment.
How to Take
Take orally, usually once daily with breakfast. Swallow whole with water, do not crush or chew.
Mechanism of Action
Stimulates insulin secretion from pancreatic beta cells by binding to sulfonylurea receptors.
Pharmacokinetics
Onset
Usually within 1 hour.
Excretion
Primarily excreted in urine (60-70%) as metabolites, with a small amount in feces.
Half life
Approximately 8-20 hours.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract. Peak plasma concentrations are reached in 2-4 hours.
Metabolism
Extensively metabolized in the liver (primarily via CYP2C9) to inactive metabolites.
Side Effects
Contraindications
- Type 1 Diabetes Mellitus
- Diabetic ketoacidosis
- Severe renal or hepatic impairment
- Hypersensitivity to gliclazide or other sulfonylureas
- Concomitant miconazole therapy
Drug Interactions
Miconazole
Potentiates hypoglycemic effect, leading to severe hypoglycemia.
Beta-blockers
Can mask symptoms of hypoglycemia.
Phenylbutazone, Alcohol
Increases hypoglycemic effect.
Corticosteroids, Diuretics
May decrease hypoglycemic effect.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Can cause severe hypoglycemia. Management includes oral glucose for conscious patients or intravenous glucose/glucagon for unconscious patients.
Pregnancy & Lactation
Not recommended during pregnancy or breastfeeding. Insulin is preferred for glycemic control.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies (e.g., DGDA)
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Ongoing studies for long-term cardiovascular outcomes in specific populations.
Lab Monitoring
- Fasting Blood Glucose (FBG)
- HbA1c
- Renal and hepatic function tests periodically.
Doctor Notes
- Educate patients on hypoglycemia symptoms and management.
- Regular monitoring of renal and hepatic function, especially in elderly patients.
Patient Guidelines
- Adhere to prescribed dosage and administration instructions.
- Monitor blood glucose regularly.
- Be aware of hypoglycemia symptoms and carry a source of sugar.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it's almost time for the next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
Driving Precautions
May cause hypoglycemia, which can impair ability to drive or operate machinery. Exercise caution.
Lifestyle Advice
- Maintain a healthy diet and regular exercise.
- Avoid excessive alcohol consumption.
- Regular follow-up with your doctor.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.