Glimitus
Generic Name
glimitus-4-mg-tablet
Manufacturer
PharmaCorp Bangladesh
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| glimitus 4 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Glimitus-4 mg tablet is an oral antidiabetic medicine used to lower blood glucose levels in adults with Type 2 Diabetes Mellitus. It belongs to the sulfonylurea class of drugs.
Uses & Indications
Dosage
Adults
Initial dose is usually 1-2 mg once daily with breakfast or the first main meal. May be increased to a maximum of 8 mg once daily based on glycemic response.
Elderly
Start with a lower initial dose of 1 mg once daily and titrate carefully to avoid hypoglycemia.
Renal_impairment
Initial dose of 1 mg once daily, with careful monitoring of renal function and blood glucose levels. Dosage adjustment may be required.
How to Take
Glimitus-4 mg tablet should be taken orally once daily with breakfast or the first main meal. Swallow the tablet whole with water; do not crush or chew.
Mechanism of Action
Glimitus primarily stimulates insulin release from the beta cells of the pancreatic islets. This insulin secretion is dependent on the presence of glucose.
Pharmacokinetics
Onset
Onset of action is typically within 2-3 hours.
Excretion
Excreted predominantly by the kidneys (approx. 60%) and feces (approx. 40%).
Half life
Elimination half-life is approximately 5-9 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 2-3 hours.
Metabolism
Extensively metabolized in the liver, primarily by CYP2C9, to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to glimitus, other sulfonylureas, or sulfonamides.
- Type 1 Diabetes Mellitus, diabetic ketoacidosis, diabetic coma.
- Severe hepatic or renal impairment.
- Pregnancy and lactation.
Drug Interactions
Decreased Hypoglycemic Effect
Corticosteroids, diuretics (thiazide), thyroid hormones, estrogens, progestogens, sympathomimetics, nicotinic acid (high doses), phenothiazines, phenytoin, rifampicin.
Increased Hypoglycemic Effect
NSAIDs, sulfonamides, fibrates, beta-blockers, alcohol, chloramphenicol, coumarin derivatives, MAO inhibitors, probenecid, salicylates, tetracyclines.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose of Glimitus can lead to severe hypoglycemia (low blood sugar). Management includes immediate administration of glucose (oral or intravenous) and close monitoring of blood sugar levels.
Pregnancy & Lactation
Glimitus is contraindicated during pregnancy and lactation. Insulin is generally preferred for glycemic control during these periods.
Side Effects
Contraindications
- Hypersensitivity to glimitus, other sulfonylureas, or sulfonamides.
- Type 1 Diabetes Mellitus, diabetic ketoacidosis, diabetic coma.
- Severe hepatic or renal impairment.
- Pregnancy and lactation.
Drug Interactions
Decreased Hypoglycemic Effect
Corticosteroids, diuretics (thiazide), thyroid hormones, estrogens, progestogens, sympathomimetics, nicotinic acid (high doses), phenothiazines, phenytoin, rifampicin.
Increased Hypoglycemic Effect
NSAIDs, sulfonamides, fibrates, beta-blockers, alcohol, chloramphenicol, coumarin derivatives, MAO inhibitors, probenecid, salicylates, tetracyclines.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose of Glimitus can lead to severe hypoglycemia (low blood sugar). Management includes immediate administration of glucose (oral or intravenous) and close monitoring of blood sugar levels.
Pregnancy & Lactation
Glimitus is contraindicated during pregnancy and lactation. Insulin is generally preferred for glycemic control during these periods.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Pharmacies and hospitals
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Patent Pending
Clinical Trials
Phase III clinical trials demonstrated Glimitus-4 mg tablet's efficacy in significantly reducing HbA1c levels and fasting plasma glucose, with a favorable safety profile compared to placebo.
Lab Monitoring
- Regular monitoring of blood glucose levels (fasting, postprandial).
- HbA1c levels every 3-6 months.
- Renal function tests (e.g., serum creatinine, eGFR).
- Liver function tests (e.g., ALT, AST).
Doctor Notes
- Emphasize patient education on hypoglycemia recognition and management.
- Carefully assess renal and hepatic function before initiating and during Glimitus therapy.
- Monitor for signs of cardiovascular events, especially in high-risk patients.
Patient Guidelines
- Take Glimitus with a meal to reduce the risk of hypoglycemia.
- Recognize the symptoms of hypoglycemia (e.g., sweating, trembling, confusion) and know how to treat it (e.g., consume sugar/juice).
- Do not skip meals or delay eating after taking the medication.
- Carry a form of fast-acting sugar (e.g., glucose tablets, hard candy) at all times.
Missed Dose Advice
If you miss a dose, take it as soon as you remember, provided it's on the same day and not too close to your next scheduled dose. Do not take a double dose to make up for a missed one.
Driving Precautions
Glimitus may cause hypoglycemia, which can impair your ability to drive or operate machinery. Exercise caution and monitor blood sugar levels before engaging in such activities.
Lifestyle Advice
- Maintain a healthy and balanced diet as recommended by your doctor or a dietitian.
- Engage in regular physical activity suitable for your health condition.
- Monitor your blood glucose regularly at home and keep a record.
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