Glory
Generic Name
Sertraline
Manufacturer
MediLife Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| glory 50 mg capsule | ৳ 3.02 | ৳ 30.20 |
Description
Overview of the medicine
Sertraline is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. It is used to treat major depressive disorder, obsessive-compulsive disorder (OCD), panic disorder, post-traumatic stress disorder (PTSD), social anxiety disorder, and premenstrual dysphoric disorder (PMDD).
Uses & Indications
Dosage
Adults
Typical starting dose for most indications is 50 mg orally once daily. Dosage may be increased gradually, typically at weekly intervals, up to a maximum of 200 mg/day depending on response and tolerability.
Elderly
Similar to adult dosage, but caution should be exercised and lower starting doses or slower titration may be considered due to potential for decreased clearance and increased sensitivity.
Renal_impairment
No dosage adjustment is generally required for mild to moderate renal impairment. Use with caution in severe renal impairment (creatinine clearance <30 mL/min).
How to Take
Take orally once daily, in the morning or evening, with or without food. Swallow the capsule whole; do not chew, crush, or open.
Mechanism of Action
Sertraline selectively inhibits the reuptake of serotonin (5-HT) into presynaptic neurons, thereby increasing the concentration of serotonin in the synaptic cleft and enhancing serotonergic neurotransmission.
Pharmacokinetics
Onset
Therapeutic effects may take 2-4 weeks to become apparent, with full effect potentially taking longer.
Excretion
Excreted in urine and feces as metabolites. Less than 2% is excreted unchanged in urine.
Half life
Approximately 26 hours (range 22-36 hours) for sertraline and 62-104 hours for the active metabolite desmethylsertraline.
Absorption
Well absorbed after oral administration, peak plasma concentrations reached 4.5-8.4 hours after dosing. Food slightly increases absorption and reduces the time to reach peak plasma levels.
Metabolism
Extensive hepatic metabolism, primarily via CYP2B6, CYP2C19, CYP2C9, CYP3A4, and CYP2D6 pathways, to inactive and one active (desmethylsertraline) metabolite.
Side Effects
Contraindications
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of stopping MAOI treatment
- Concomitant use with Pimozide
- Hypersensitivity to sertraline or any component of the formulation
Drug Interactions
MAOIs
Serious, sometimes fatal, reactions including Serotonin Syndrome.
NSAIDs
Increased risk of gastrointestinal bleeding.
Pimozide
Increased pimozide levels and cardiotoxicity.
Triptans
Increased risk of Serotonin Syndrome.
Warfarin
Potentiation of anticoagulant effect, increased bleeding risk.
Other Serotonergic Drugs (e.g., other SSRIs, SNRIs, Fentanyl, Lithium, Tramadol, St. John's Wort)
Increased risk of Serotonin Syndrome.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, vomiting, tachycardia, tremor, agitation, dizziness, and rarely, convulsions and coma. Management is supportive and symptomatic; maintain airway, monitor cardiac and vital signs. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Sertraline is excreted in human breast milk; therefore, caution should be exercised when administered to a nursing woman.
Side Effects
Contraindications
- Concomitant use with Monoamine Oxidase Inhibitors (MAOIs) or within 14 days of stopping MAOI treatment
- Concomitant use with Pimozide
- Hypersensitivity to sertraline or any component of the formulation
Drug Interactions
MAOIs
Serious, sometimes fatal, reactions including Serotonin Syndrome.
NSAIDs
Increased risk of gastrointestinal bleeding.
Pimozide
Increased pimozide levels and cardiotoxicity.
Triptans
Increased risk of Serotonin Syndrome.
Warfarin
Potentiation of anticoagulant effect, increased bleeding risk.
Other Serotonergic Drugs (e.g., other SSRIs, SNRIs, Fentanyl, Lithium, Tramadol, St. John's Wort)
Increased risk of Serotonin Syndrome.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, vomiting, tachycardia, tremor, agitation, dizziness, and rarely, convulsions and coma. Management is supportive and symptomatic; maintain airway, monitor cardiac and vital signs. Activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Sertraline is excreted in human breast milk; therefore, caution should be exercised when administered to a nursing woman.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2 to 3 years from manufacturing date
Availability
Available in pharmacies and hospitals
Approval Status
FDA Approved, DGDA Registered
Patent Status
Generic available (Off-patent)
WHO Essential Medicine
YesClinical Trials
Sertraline has undergone extensive clinical trials supporting its efficacy and safety for approved indications. Ongoing research continues to explore its use in other conditions.
Lab Monitoring
- Monitor serum sodium levels, especially in elderly patients or those on diuretics, due to risk of hyponatremia.
- Monitor liver function tests periodically, especially in patients with hepatic impairment.
Doctor Notes
- Initiate at a low dose and titrate gradually to minimize side effects.
- Monitor patients, especially young adults, for worsening depression or suicidality when initiating or changing dose.
- Counsel patients on potential sexual dysfunction and discontinuation syndrome.
- Be aware of significant drug interactions, particularly with MAOIs and other serotonergic agents.
Patient Guidelines
- Take exactly as prescribed by your doctor. Do not stop taking this medicine suddenly, as it may cause withdrawal symptoms; dosage should be gradually reduced under medical supervision.
- It may take several weeks to feel the full benefits of this medicine. Continue taking it even if you don't feel better immediately.
- Report any unusual changes in mood or behavior, especially suicidal thoughts, to your doctor immediately.
- Avoid alcohol while taking this medicine.
- Do not drive or operate heavy machinery until you know how this medicine affects you.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause dizziness, drowsiness, or visual disturbances. Patients should be cautioned about operating hazardous machinery, including automobiles, until they are reasonably certain that sertraline therapy does not adversely affect their ability to engage in such activities.
Lifestyle Advice
- Engage in regular physical activity and maintain a balanced diet.
- Practice stress-reduction techniques like mindfulness or meditation.
- Ensure adequate sleep.
- Maintain open communication with your healthcare provider about your progress and any concerns.
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