Glucium-D
Generic Name
Glucosamine Sulfate 750 mg + Cholecalciferol 400 IU Tablet
Manufacturer
Leading Pharmaceutical Company
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| glucium d 750 mg tablet | ৳ 12.00 | ৳ 120.00 |
Description
Overview of the medicine
Glucium-D 750 mg Tablet is a nutritional supplement combining Glucosamine Sulfate and Cholecalciferol (Vitamin D3). It is primarily used to support joint health, reduce symptoms of osteoarthritis such as pain and stiffness, and maintain healthy bones.
Uses & Indications
Dosage
Adults
One tablet daily, or as directed by a physician.
Elderly
No specific dosage adjustment is generally required, follow adult dosage or physician's advice.
Renal_impairment
Use with caution in severe renal impairment. Consult a physician.
How to Take
Take the tablet orally with a glass of water, with or without food. It is recommended to take it at the same time each day for better compliance.
Mechanism of Action
Glucosamine Sulfate is a natural compound found in healthy cartilage. It serves as a building block for glycosaminoglycans (GAGs) and proteoglycans, essential components of cartilage matrix, which helps in cartilage regeneration and joint repair. Cholecalciferol (Vitamin D3) aids in the absorption of calcium and phosphorus, crucial for bone mineralization and overall bone health.
Pharmacokinetics
Onset
Glucosamine: Therapeutic effects may take several weeks to months. Cholecalciferol: Effects on calcium levels can be seen within days.
Excretion
Glucosamine: Primarily excreted renally, with some fecal excretion. Cholecalciferol: Excreted primarily via bile into the feces.
Half life
Glucosamine: Approximately 15 hours. Cholecalciferol: Parent compound 24 hours, active metabolite 1,25-(OH)2D3 has a half-life of 4-6 hours.
Absorption
Glucosamine: Approximately 25-30% absorbed orally. Cholecalciferol: Well absorbed from the small intestine, absorption is enhanced with fatty meals.
Metabolism
Glucosamine: Primarily metabolized in the liver to smaller molecules. Cholecalciferol: Hydroxylated in the liver to 25-hydroxyvitamin D3, then in the kidneys to the active form 1,25-dihydroxyvitamin D3.
Side Effects
Contraindications
- •Known hypersensitivity to Glucosamine, Cholecalciferol, or any component of the tablet.
- •Allergy to shellfish (Glucosamine is often derived from shellfish).
- •Hypercalcemia or conditions resulting in hypercalcemia.
- •Severe renal or hepatic impairment without consulting a doctor.
Drug Interactions
Warfarin
Glucosamine may increase the anticoagulant effect of warfarin, increasing the risk of bleeding. Monitor INR closely.
Thiazide Diuretics
May increase the risk of hypercalcemia when co-administered with Vitamin D.
Antidiabetic agents
Glucosamine may affect glucose metabolism; monitor blood glucose levels in diabetic patients.
Certain Antacids (containing Aluminum)
May reduce Vitamin D absorption if taken concurrently.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, and in the case of excessive Vitamin D, hypercalcemia (symptoms like weakness, fatigue, headache, loss of appetite). In case of suspected overdose, seek immediate medical attention.
Pregnancy & Lactation
Consult a physician before use during pregnancy and lactation. This product should generally be avoided unless the potential benefits outweigh the possible risks to the fetus or infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Generally 2-3 years from the date of manufacture. Check the expiry date on the packaging.
Availability
Available in pharmacies, supermarkets, and online stores
Approval Status
Regulated as a dietary supplement by relevant authorities
Patent Status
Off-patent (for active ingredients)
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Global Brand Names
International brand names for this medicine
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