GlycoB
Generic Name
Biganib
Manufacturer
PharmaCorp Bangladesh (fictional)
Country
Bangladesh
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Description
Overview of the medicine
Biganib is an oral antidiabetic drug used to treat type 2 diabetes mellitus. It helps to lower blood glucose levels by improving insulin sensitivity and reducing hepatic glucose production. It can be used alone or in combination with other antidiabetic agents.
Uses & Indications
Dosage
Adults
Initial dose: 500 mg orally once or twice daily with meals. Dose may be gradually increased to a maximum of 2000 mg/day.
Elderly
Start with a lower dose (e.g., 250 mg once daily) and adjust cautiously based on renal function.
Renal_impairment
Contraindicated in severe renal impairment (eGFR <30 mL/min). Dose adjustment required for eGFR 30-60 mL/min. Consult physician.
How to Take
Take orally with meals to reduce gastrointestinal side effects. Swallow the tablet whole with water; do not crush or chew.
Mechanism of Action
Biganib primarily acts by decreasing hepatic glucose production (gluconeogenesis), increasing insulin sensitivity in peripheral tissues (like muscle and fat cells), and delaying intestinal absorption of glucose. It does not stimulate insulin secretion, thus it typically does not cause hypoglycemia.
Pharmacokinetics
Onset
Onset of glucose-lowering effect is typically within 2 hours.
Excretion
Primarily excreted unchanged by the kidneys via glomerular filtration and tubular secretion.
Half life
Plasma elimination half-life is approximately 4-9 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract; absolute bioavailability is approximately 50-60%.
Metabolism
Not extensively metabolized in the liver. Excreted largely unchanged.
Side Effects
Contraindications
- Hypersensitivity to Biganib or any component of the formulation.
- Severe renal impairment (eGFR <30 mL/min).
- Acute or chronic metabolic acidosis, including diabetic ketoacidosis.
- Dehydration, acute heart failure, acute myocardial infarction, septicemia.
Drug Interactions
Alcohol
Increases the risk of lactic acidosis. Avoid excessive alcohol intake.
Cimetidine
May increase Biganib plasma concentrations; consider dose reduction.
Diuretics (especially loop diuretics)
May increase the risk of lactic acidosis due to potential renal function impairment.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Overdose may lead to lactic acidosis, which is a medical emergency. Treatment involves symptomatic and supportive measures, including hemodialysis to remove Biganib and correct acidosis.
Pregnancy & Lactation
Consult a doctor. Generally, insulin is preferred for glycemic control during pregnancy. Biganib is excreted in breast milk; caution is advised during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to Biganib or any component of the formulation.
- Severe renal impairment (eGFR <30 mL/min).
- Acute or chronic metabolic acidosis, including diabetic ketoacidosis.
- Dehydration, acute heart failure, acute myocardial infarction, septicemia.
Drug Interactions
Alcohol
Increases the risk of lactic acidosis. Avoid excessive alcohol intake.
Cimetidine
May increase Biganib plasma concentrations; consider dose reduction.
Diuretics (especially loop diuretics)
May increase the risk of lactic acidosis due to potential renal function impairment.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Overdose may lead to lactic acidosis, which is a medical emergency. Treatment involves symptomatic and supportive measures, including hemodialysis to remove Biganib and correct acidosis.
Pregnancy & Lactation
Consult a doctor. Generally, insulin is preferred for glycemic control during pregnancy. Biganib is excreted in breast milk; caution is advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
3 years from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA (fictional)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Phase III clinical trials completed demonstrating efficacy and safety. Ongoing Phase IV trials for long-term safety and effectiveness.
Lab Monitoring
- Renal function (eGFR) should be assessed before starting Biganib and at least annually thereafter.
- Blood glucose and HbA1c levels should be monitored regularly.
- Consider monitoring Vitamin B12 levels periodically, especially in patients with risk factors for deficiency or on long-term therapy.
Doctor Notes
- Emphasize regular monitoring of renal function and blood glucose.
- Educate patients on symptoms of lactic acidosis and need for immediate medical attention if suspected.
- Consider Vitamin B12 supplementation for long-term users, especially elderly or those with malabsorption.
Patient Guidelines
- Take Biganib exactly as prescribed by your doctor.
- Inform your doctor if you experience unusual muscle pain, difficulty breathing, unusual stomach discomfort, or feeling very weak or tired.
- Do not stop taking Biganib without consulting your doctor.
- Always carry identification stating you have diabetes.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Biganib alone does not typically cause hypoglycemia, so it should not affect your ability to drive or operate machinery. However, if used in combination with other antidiabetic agents that can cause hypoglycemia, caution is advised.
Lifestyle Advice
- Maintain a healthy diet and regular exercise regimen to help control blood sugar levels.
- Avoid excessive alcohol consumption.
- Regularly monitor your blood glucose levels as advised by your doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.