gored-mr
Generic Name
Gliclazide Modified Release
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| gored mr 60 mg tablet | ৳ 11.00 | ৳ 154.00 |
Description
Overview of the medicine
Gored-MR 60 mg tablet is an oral anti-diabetic medication used for the management of Type 2 Diabetes Mellitus.
Uses & Indications
Dosage
Adults
Initial dose 30 mg once daily, titrated up to 120 mg once daily based on blood glucose levels. To be taken with breakfast.
Elderly
Start with a lower dose (e.g., 30 mg once daily) and adjust cautiously.
Renal_impairment
No dose adjustment is generally required for mild to moderate renal impairment, but caution is advised. Not recommended in severe impairment.
How to Take
Take orally once daily, preferably with breakfast. Swallow the tablet whole; do not chew or crush.
Mechanism of Action
Gliclazide stimulates insulin secretion from the pancreatic beta cells, thereby lowering blood glucose levels.
Pharmacokinetics
Onset
2-4 hours
Excretion
Mainly excreted in the urine as metabolites.
Half life
Approximately 12-20 hours
Absorption
Well absorbed after oral administration.
Metabolism
Extensively metabolized in the liver.
Side Effects
Contraindications
- Type 1 Diabetes Mellitus
- Diabetic ketoacidosis
- Severe renal or hepatic impairment
- Hypersensitivity to gliclazide or other sulfonylureas
- Concomitant use with miconazole
Drug Interactions
Miconazole
Potentiates hypoglycemic effect, leading to severe hypoglycemia.
Beta-blockers, ACE inhibitors
May mask or enhance hypoglycemic symptoms.
Corticosteroids, Diuretics, Barbiturates, Estrogens
May reduce the hypoglycemic effect.
Phenylbutazone, Alcohol, NSAIDs, Sulfonamides, Salicylates
May enhance the hypoglycemic effect.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose can lead to severe hypoglycemia, which may require immediate glucose administration (oral or intravenous) and careful monitoring.
Pregnancy & Lactation
Not recommended during pregnancy or lactation. Consult a doctor for alternative treatments.
Side Effects
Contraindications
- Type 1 Diabetes Mellitus
- Diabetic ketoacidosis
- Severe renal or hepatic impairment
- Hypersensitivity to gliclazide or other sulfonylureas
- Concomitant use with miconazole
Drug Interactions
Miconazole
Potentiates hypoglycemic effect, leading to severe hypoglycemia.
Beta-blockers, ACE inhibitors
May mask or enhance hypoglycemic symptoms.
Corticosteroids, Diuretics, Barbiturates, Estrogens
May reduce the hypoglycemic effect.
Phenylbutazone, Alcohol, NSAIDs, Sulfonamides, Salicylates
May enhance the hypoglycemic effect.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose can lead to severe hypoglycemia, which may require immediate glucose administration (oral or intravenous) and careful monitoring.
Pregnancy & Lactation
Not recommended during pregnancy or lactation. Consult a doctor for alternative treatments.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years from manufacturing date
Availability
Pharmacies nationwide
Approval Status
Approved
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have demonstrated the efficacy of Gliclazide Modified Release in achieving glycemic control and reducing the risk of microvascular complications in patients with Type 2 Diabetes Mellitus.
Lab Monitoring
- Regular monitoring of blood glucose levels
- HbA1c
- Renal function tests
- Liver function tests
Doctor Notes
- Emphasize patient education regarding hypoglycemia symptoms and management.
- Dose titration should be done carefully based on individual patient's blood glucose response.
- Regular monitoring of blood glucose and HbA1c is crucial.
Patient Guidelines
- Take the medicine exactly as prescribed by your doctor.
- Do not skip meals and maintain a regular eating schedule.
- Be aware of the symptoms of hypoglycemia and how to treat them (e.g., consuming sugary foods).
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
Caution is advised when driving or operating machinery, especially at the beginning of treatment or if experiencing hypoglycemic episodes.
Lifestyle Advice
- Maintain a balanced diet and regular exercise routine.
- Limit alcohol intake.
- Regularly consult with your doctor and follow their advice for diabetes management.
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