Gyned
Generic Name
Clotrimazole + Clindamycin Vaginal Suppository
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| gyned vaginal suppository | ৳ 35.00 | N/A |
Description
Overview of the medicine
Gyned vaginal suppository is a combination medication used for the local treatment of mixed vaginal infections caused by fungi and bacteria. It contains Clotrimazole, an antifungal agent, and Clindamycin, an antibacterial agent.
Uses & Indications
Dosage
Adults
Insert one suppository intravaginally once daily, preferably at bedtime, for 3 to 7 consecutive days depending on the severity of the infection and clinical response. Typically a 7-day course is recommended for optimal results.
Elderly
No specific dosage adjustment required for elderly patients.
Renal_impairment
No specific dosage adjustment required for renal impairment as systemic absorption is minimal.
How to Take
For intravaginal use only. Insert the suppository deep into the vagina, preferably while lying down, at bedtime. Use the applicator provided if applicable.
Mechanism of Action
Clotrimazole acts by inhibiting the biosynthesis of ergosterol, an essential component of the fungal cell membrane, leading to increased membrane permeability and leakage of cellular contents. Clindamycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thus preventing peptide bond formation.
Pharmacokinetics
Onset
Relief of symptoms may begin within a few days of treatment.
Excretion
Mainly excreted via feces (Clotrimazole) and urine/feces (Clindamycin) after systemic absorption, though vaginal absorption is minimal.
Half life
Systemic half-life not clinically relevant due to minimal absorption.
Absorption
Minimal systemic absorption after vaginal administration. Clotrimazole is poorly absorbed from the vagina. Clindamycin also has low systemic absorption from the vagina.
Metabolism
Clotrimazole is metabolized in the liver to inactive metabolites. Clindamycin is metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Clotrimazole, Clindamycin, or any component of the suppository
- History of regional enteritis, ulcerative colitis, or antibiotic-associated colitis
Drug Interactions
Warfarin
Clindamycin may potentiate the effects of vitamin K antagonists like warfarin, increasing bleeding risk.
Other vaginal products
Concurrent use of other intravaginal products during treatment should be avoided.
Neuromuscular blocking agents
Clindamycin has neuromuscular blocking properties and should be used with caution in patients receiving such agents.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Due to minimal systemic absorption, overdose with vaginal suppositories is unlikely to cause serious systemic effects. In case of accidental oral ingestion, gastric lavage may be performed if necessary. Symptomatic and supportive treatment should be provided.
Pregnancy & Lactation
Use in pregnancy only if clearly needed and the potential benefits outweigh the potential risks. Consult a doctor before use during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to Clotrimazole, Clindamycin, or any component of the suppository
- History of regional enteritis, ulcerative colitis, or antibiotic-associated colitis
Drug Interactions
Warfarin
Clindamycin may potentiate the effects of vitamin K antagonists like warfarin, increasing bleeding risk.
Other vaginal products
Concurrent use of other intravaginal products during treatment should be avoided.
Neuromuscular blocking agents
Clindamycin has neuromuscular blocking properties and should be used with caution in patients receiving such agents.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Due to minimal systemic absorption, overdose with vaginal suppositories is unlikely to cause serious systemic effects. In case of accidental oral ingestion, gastric lavage may be performed if necessary. Symptomatic and supportive treatment should be provided.
Pregnancy & Lactation
Use in pregnancy only if clearly needed and the potential benefits outweigh the potential risks. Consult a doctor before use during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
DGDA Approved
Patent Status
Generic available
Clinical Trials
Extensive clinical trials support the efficacy and safety of Clotrimazole and Clindamycin for vaginal infections, both individually and in combination.
Lab Monitoring
- No specific routine lab monitoring required for vaginal suppositories.
Doctor Notes
- Advise patients on proper administration technique.
- Emphasize completion of the full course to prevent recurrence.
- Rule out other causes of vaginal symptoms before prescribing.
Patient Guidelines
- Complete the full course of treatment even if symptoms improve.
- Avoid sexual intercourse during treatment to prevent re-infection and irritation.
- Do not use tampons, douches, or other vaginal products during treatment.
- Wear cotton underwear and avoid tight-fitting clothing to allow air circulation.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double dose.
Driving Precautions
Gyned vaginal suppositories are not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain good personal hygiene.
- Avoid perfumed soaps or harsh detergents in the vaginal area.
- Wipe from front to back after using the toilet.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.