H-QUIN
Generic Name
Hydroxychloroquine Sulfate
Manufacturer
Reputable Pharmaceutical Co.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| h quin 200 mg tablet | ৳ 15.00 | ৳ 150.00 |
Description
Overview of the medicine
Hydroxychloroquine is an antimalarial and anti-inflammatory drug used to prevent and treat malaria, and to treat autoimmune diseases like lupus erythematosus and rheumatoid arthritis.
Uses & Indications
Dosage
Adults
Varies by indication. For rheumatoid arthritis, initially 400 mg daily in divided doses, then 200-400 mg daily. For malaria prophylaxis, 400 mg once weekly.
Elderly
Initiate with lower doses and monitor for adverse effects due to potential decreased renal/hepatic function.
Renal_impairment
Dose reduction may be necessary; caution advised.
How to Take
Administer orally, usually with food or milk to minimize gastrointestinal upset.
Mechanism of Action
Hydroxychloroquine works by interfering with parasitic growth in red blood cells. In autoimmune diseases, it modulates immune responses, possibly by inhibiting antigen presentation, lysosomal function, and cytokine production.
Pharmacokinetics
Onset
For malaria, within hours; for rheumatic conditions, weeks to months.
Excretion
Primarily via urine, with a small amount excreted in feces.
Half life
Long elimination half-life, ranging from 32 to 50 days for the parent drug and metabolites.
Absorption
Rapidly absorbed from the GI tract; bioavailability varies but is generally good. Peak plasma concentrations reached in about 3-4 hours.
Metabolism
Extensively metabolized in the liver to active metabolites (e.g., desethylchloroquine).
Side Effects
Contraindications
- Hypersensitivity to 4-aminoquinoline compounds
- Pre-existing maculopathy of the eye
- Long-term use in children (contraindicated by some authorities)
Drug Interactions
Digoxin
May increase digoxin serum levels.
Antacids
May decrease absorption of hydroxychloroquine.
Mefloquine
Increased risk of seizures.
Other QT prolonging drugs
Increased risk of arrhythmias.
Insulin/Hypoglycemic agents
May enhance the effects of these drugs.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include headache, drowsiness, visual disturbances, cardiovascular collapse, and seizures. Treatment is symptomatic and supportive, including gastric lavage and activated charcoal.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and potential benefits outweigh risks. Excreted in breast milk, use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to 4-aminoquinoline compounds
- Pre-existing maculopathy of the eye
- Long-term use in children (contraindicated by some authorities)
Drug Interactions
Digoxin
May increase digoxin serum levels.
Antacids
May decrease absorption of hydroxychloroquine.
Mefloquine
Increased risk of seizures.
Other QT prolonging drugs
Increased risk of arrhythmias.
Insulin/Hypoglycemic agents
May enhance the effects of these drugs.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include headache, drowsiness, visual disturbances, cardiovascular collapse, and seizures. Treatment is symptomatic and supportive, including gastric lavage and activated charcoal.
Pregnancy & Lactation
Use during pregnancy only if clearly needed and potential benefits outweigh risks. Excreted in breast milk, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
Approved by major regulatory bodies
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Extensively studied for its approved indications; ongoing research for other potential uses and safety profiles.
Lab Monitoring
- Baseline and annual ophthalmologic examination (including visual acuity, fundoscopy, visual fields, and OCT)
- Complete blood count (CBC)
- Liver function tests
- Renal function tests
Doctor Notes
- Emphasize the importance of baseline and annual ophthalmic screening.
- Counsel patients on potential cardiac and ocular toxicities.
- Monitor for signs of hypoglycemia, especially in diabetic patients.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not stop taking the medicine without consulting your doctor.
- Report any vision changes immediately.
- Attend regular eye examinations.
Missed Dose Advice
If a dose is missed, take it as soon as remembered, unless it is almost time for the next dose. Do not double the dose.
Driving Precautions
May cause blurred vision, dizziness, or lightheadedness. Avoid driving or operating machinery if affected.
Lifestyle Advice
- Maintain a healthy diet.
- Avoid excessive alcohol consumption.
- Protect skin from sun exposure, especially if you have lupus.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.