Haemozin-TR
Generic Name
Ferrous Ascorbate (equivalent to Elemental Iron 150 mg) and Folic Acid (1.5 mg)
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| haemozin tr 150 mg capsule | ৳ 3.00 | ৳ 24.00 |
Description
Overview of the medicine
Haemozin-TR 150 mg Capsule is an iron and folic acid supplement used to treat and prevent iron deficiency anemia, particularly during pregnancy and lactation, or in conditions requiring increased iron intake.
Uses & Indications
Dosage
Adults
1 capsule once daily, or as directed by physician. It's usually taken on an empty stomach for better absorption, but can be taken with food to minimize GI upset.
Elderly
Same as adult dosage, but caution with existing comorbidities. Consult physician.
Renal_impairment
Generally safe, but use with caution in patients undergoing dialysis. Consult physician.
How to Take
Oral. Take with a glass of water. For best absorption, take on an empty stomach. If gastrointestinal upset occurs, it may be taken with food.
Mechanism of Action
Elemental iron is a vital component of hemoglobin, myoglobin, and several enzymes, crucial for oxygen transport and cellular respiration. Folic acid is essential for DNA synthesis and cell division, particularly important for erythropoiesis (red blood cell formation).
Pharmacokinetics
Onset
Hematological response seen within 3-4 weeks, maximum effect in 2-4 months.
Excretion
Iron is primarily excreted via feces (unabsorbed iron), urine, and sweat in trace amounts. Folic acid is largely excreted in the urine as metabolites, with some un-metabolized folic acid.
Half life
Iron half-life is variable due to body storage. Folic acid: 3-6 hours.
Absorption
Iron from ferrous ascorbate is well absorbed in the duodenum and upper jejunum, typically 10-30% of ingested dose, influenced by iron stores and dietary factors. Folic acid is rapidly absorbed from the GI tract, primarily in the duodenum and upper jejunum.
Metabolism
Iron is not metabolized; it is incorporated into proteins or stored. Folic acid is converted to its active form, tetrahydrofolate, in the liver and gastrointestinal cells.
Side Effects
Contraindications
- Hypersensitivity to iron preparations or folic acid.
- Hemochromatosis and other iron overload syndromes.
- Non-iron deficiency anemias (e.g., hemolytic anemia, aplastic anemia, sideroblastic anemia) unless iron deficiency coexists.
- Frequent blood transfusions.
Drug Interactions
Phenytoin
Folic acid may decrease phenytoin levels.
Antacids & PPIs
May reduce iron absorption. Separate administration by several hours.
Chloramphenicol
May delay the hematologic response to iron therapy.
Thyroid Hormones
Iron may reduce absorption of levothyroxine. Separate administration by at least 4 hours.
Levodopa, Methyldopa
Iron may reduce absorption.
Tetracyclines & Quinolones
Iron may decrease absorption of these antibiotics. Administer iron 2 hours before or 4-6 hours after.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe nausea, vomiting, abdominal pain, diarrhea (potentially bloody), lethargy, tachycardia, hypotension. Severe overdose can lead to metabolic acidosis, shock, liver necrosis, and coma. Treatment involves gastric lavage, chelation therapy (e.g., deferoxamine), and supportive care.
Pregnancy & Lactation
Essential during pregnancy and lactation to meet increased iron and folate demands and prevent maternal and fetal anemia. Consult a healthcare professional before use.
Side Effects
Contraindications
- Hypersensitivity to iron preparations or folic acid.
- Hemochromatosis and other iron overload syndromes.
- Non-iron deficiency anemias (e.g., hemolytic anemia, aplastic anemia, sideroblastic anemia) unless iron deficiency coexists.
- Frequent blood transfusions.
Drug Interactions
Phenytoin
Folic acid may decrease phenytoin levels.
Antacids & PPIs
May reduce iron absorption. Separate administration by several hours.
Chloramphenicol
May delay the hematologic response to iron therapy.
Thyroid Hormones
Iron may reduce absorption of levothyroxine. Separate administration by at least 4 hours.
Levodopa, Methyldopa
Iron may reduce absorption.
Tetracyclines & Quinolones
Iron may decrease absorption of these antibiotics. Administer iron 2 hours before or 4-6 hours after.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms include severe nausea, vomiting, abdominal pain, diarrhea (potentially bloody), lethargy, tachycardia, hypotension. Severe overdose can lead to metabolic acidosis, shock, liver necrosis, and coma. Treatment involves gastric lavage, chelation therapy (e.g., deferoxamine), and supportive care.
Pregnancy & Lactation
Essential during pregnancy and lactation to meet increased iron and folate demands and prevent maternal and fetal anemia. Consult a healthcare professional before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months
Availability
Available in pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesClinical Trials
Extensively studied efficacy and safety in iron deficiency anemia and during pregnancy. Data available in medical literature for Ferrous Ascorbate and Folic Acid combinations.
Lab Monitoring
- Complete Blood Count (CBC) including Hemoglobin (Hb), Hematocrit (Hct), Mean Corpuscular Volume (MCV)
- Serum Ferritin
- Serum Iron and Total Iron Binding Capacity (TIBC)
Doctor Notes
- Advise patients about potential dark stools.
- Counsel on proper administration to maximize absorption and minimize GI side effects.
- Monitor hemoglobin and ferritin levels periodically.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Do not crush or chew the capsule; swallow whole.
- If stomach upset occurs, try taking it with food, but avoid dairy, tea, and coffee.
- Keep out of reach of children.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Generally no known effects on driving ability. However, if you experience dizziness or fatigue, avoid driving or operating machinery.
Lifestyle Advice
- Maintain a balanced diet rich in iron (e.g., red meat, leafy greens, fortified cereals) and Vitamin C (e.g., citrus fruits).
- Avoid excessive consumption of tea and coffee, especially around medication times.
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