Halotop
Generic Name
Halobetasol Propionate
Manufacturer
Healthcare Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| halotop 001 lotion | ৳ 160.00 | N/A |
Description
Overview of the medicine
Halotop 0.05% Lotion contains Halobetasol Propionate, a high-potency topical corticosteroid, used for the relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected skin areas once or twice daily, as directed by a physician. Treatment should be limited to 2 consecutive weeks and total dosage should not exceed 50g per week.
Elderly
No specific dosage adjustment required, but caution advised due to potential for thinner skin and increased absorption.
Renal_impairment
No specific dosage adjustment for topical use; however, systemic exposure should be monitored with prolonged use.
How to Take
For external use only. Apply a thin film to the affected skin area. Rub in gently and completely. Do not use with occlusive dressings unless directed by a physician. Avoid contact with eyes and mucous membranes.
Mechanism of Action
Halobetasol Propionate is a corticosteroid that acts by inducing phospholipase A2 inhibitory proteins, called lipocortins. These proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid.
Pharmacokinetics
Onset
Within hours to days of application.
Excretion
Excreted by the kidneys and in bile.
Half life
Not well established for topical application; systemic half-life of corticosteroids generally varies.
Absorption
Systemic absorption of topical corticosteroids can occur, especially with prolonged use, large surface areas, or occlusive dressings. Absorption varies by site, vehicle, and skin integrity. Higher absorption in inflamed skin.
Metabolism
Primarily metabolized in the liver.
Side Effects
Contraindications
- Hypersensitivity to Halobetasol Propionate or any component of the formulation
- Primary cutaneous viral infections (e.g., herpes simplex, varicella)
- Fungal infections
- Bacterial infections (unless concomitant anti-infective therapy is used)
- Rosacea
- Perioral dermatitis
- Acne vulgaris
- Perianal and genital pruritus
Drug Interactions
Immunosuppressants
May increase the risk of infection.
Other topical preparations
Concurrent use of other topical preparations on the same area should be avoided unless medically advised to prevent altered absorption or irritation.
Storage
Store at controlled room temperature (20°C to 25°C). Protect from freezing and excessive heat. Keep the tube tightly closed when not in use. Do not refrigerate.
Overdose
Acute overdose with topical corticosteroids is rare. However, prolonged or excessive use may lead to systemic effects such as HPA axis suppression, Cushing's syndrome, hyperglycemia, and glucosuria. Treatment is symptomatic and supportive; gradual withdrawal of the drug may be necessary.
Pregnancy & Lactation
Pregnancy Category C. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Caution is advised when administered to a nursing woman due to potential systemic absorption.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies, drugstores
Approval Status
Approved (local regulatory authority, e.g., DGDA)
Patent Status
Generic available, original patent expired
Clinical Trials
Extensive clinical trials have demonstrated Halobetasol Propionate's efficacy and safety in treating various corticosteroid-responsive dermatoses. Studies often compare it to other potent corticosteroids.
Lab Monitoring
- No routine lab monitoring required for topical use. For prolonged use over large areas, monitoring for HPA axis suppression (e.g., plasma cortisol levels) may be considered.
Doctor Notes
- Emphasize the high potency of Halobetasol Propionate and the importance of limiting treatment duration to avoid adverse effects.
- Advise patients against using on face, groin, or axillae unless specifically instructed.
- Counsel on the signs of HPA axis suppression and when to seek medical attention.
Patient Guidelines
- Apply a thin layer to affected skin only.
- Wash hands before and after application.
- Avoid contact with eyes, mouth, and other mucous membranes.
- Do not cover treated area with occlusive bandages unless advised by doctor.
- Do not use for longer than 2 weeks unless specifically directed by a doctor.
- Keep out of reach of children.
Missed Dose Advice
If a dose is missed, apply it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not apply a double dose to make up for a missed one.
Driving Precautions
Halotop 0.05% Lotion is for topical use and is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Keep skin moisturized regularly.
- Avoid harsh soaps and irritants that may worsen skin conditions.
- Wear loose, comfortable clothing over affected areas.
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Global Brand Names
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