Healer
Generic Name
Esomeprazole 20 mg Capsule
Manufacturer
Acme Pharma
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| healer 20 mg capsule | ৳ 4.00 | N/A |
Description
Overview of the medicine
Healer 20 mg Capsule contains Esomeprazole, a proton pump inhibitor (PPI) that reduces the amount of acid produced in the stomach. It is used to treat conditions caused by too much stomach acid, such as gastroesophageal reflux disease (GERD), ulcers, and certain types of indigestion.
Uses & Indications
Dosage
Adults
For GERD: 20-40 mg once daily for 4-8 weeks. For Erosive Esophagitis: 20-40 mg once daily for 4-8 weeks. For H. pylori eradication: 20 mg twice daily with appropriate antibiotics for 7-10 days. For Zollinger-Ellison Syndrome: Initial dose of 40 mg twice daily, adjusted as needed.
Elderly
No specific dosage adjustment is generally required, but caution is advised in patients with severe hepatic impairment.
Renal_impairment
No dosage adjustment is required for patients with renal impairment.
How to Take
Healer 20 mg Capsule should be swallowed whole with water. Do not chew or crush the capsule. It is best taken at least 30-60 minutes before a meal, preferably in the morning.
Mechanism of Action
Esomeprazole is a proton pump inhibitor that specifically inhibits the H+/K+-ATPase enzyme system (proton pump) located at the secretory surface of the parietal cells in the stomach. This inhibition blocks the final step of acid production, leading to a reduction in gastric acid secretion.
Pharmacokinetics
Onset
Within 1 hour (acid reduction)
Excretion
Approximately 80% is excreted in the urine as metabolites, and the remainder in the feces.
Half life
Approximately 1-1.5 hours
Absorption
Rapidly absorbed after oral administration. Bioavailability is about 50-68% (increasing with repeated dosing). Peak plasma concentration is reached within 1-2 hours.
Metabolism
Extensively metabolized in the liver by the cytochrome P450 (CYP) enzyme system, mainly CYP2C19 and CYP3A4.
Side Effects
Contraindications
- •Hypersensitivity to esomeprazole, substituted benzimidazoles, or any component of the formulation.
- •Concomitant use with nelfinavir (an antiretroviral drug).
Drug Interactions
Diazepam
Delayed elimination of diazepam.
Warfarin
Increased INR and prothrombin time, monitor closely.
Clopidogrel
Reduced antiplatelet effect of clopidogrel.
Methotrexate
Possible increased methotrexate levels, especially with high doses.
Nelfinavir/Atazanavir
Reduced plasma levels of these antiretrovirals.
Ketoconazole/Itraconazole
Reduced absorption due to increased gastric pH.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
There is limited experience with overdose. Symptoms may include gastrointestinal disturbances, weakness, and central nervous system effects. Treatment is symptomatic and supportive. Esomeprazole is not readily dialyzable.
Pregnancy & Lactation
Pregnancy Category B. Studies in animals have not shown a risk, but there are no adequate and well-controlled studies in pregnant women. Use during pregnancy only if clearly needed. Excretion into breast milk is unknown; caution is advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from the date of manufacture, refer to the product packaging for exact details.
Availability
Pharmacies, Hospitals
Approval Status
Approved by Regulatory Authorities (e.g., DGDA)
Patent Status
Patent expired for generic versions
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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