Helo
Generic Name
Pantoprazole Sodium
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| helo 20 mg injection | ৳ 1,200.00 | N/A |
Description
Overview of the medicine
Helo 20 mg Injection contains Pantoprazole Sodium, a proton pump inhibitor, used to treat conditions caused by excessive stomach acid production.
Uses & Indications
Dosage
Adults
20 mg once daily by intravenous infusion, typically for up to 7 days, or as directed by physician. Dosage may be increased to 40 mg once daily for more severe conditions.
Elderly
No specific dose adjustment is generally required, but caution is advised in those with severe hepatic impairment.
Renal_impairment
No dose adjustment is necessary for patients with renal impairment.
How to Take
Administer intravenously over 2 to 15 minutes, typically once daily. Reconstitute lyophilized powder with appropriate solvent as per manufacturer's instructions.
Mechanism of Action
Irreversibly binds to and inactivates the H+/K+-ATPase proton pump in parietal cells, thereby inhibiting gastric acid secretion.
Pharmacokinetics
Onset
Within 15-30 minutes
Excretion
Primarily via urine (approx. 80%) and feces (approx. 20%)
Half life
Approximately 1 hour (terminal half-life)
Absorption
Rapidly absorbed after intravenous administration, achieving peak plasma concentration quickly.
Metabolism
Extensively metabolized in the liver via CYP2C19 and CYP3A4 enzymes.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole or any component of the formulation
- Hypersensitivity to substituted benzimidazoles
Drug Interactions
Warfarin
Increased INR and bleeding risk.
Clopidogrel
Potential for reduced antiplatelet effect (clinical significance debated).
Methotrexate
Increased methotrexate levels, especially high doses.
Atazanavir/Nelfinavir
Reduced absorption, decreased antiviral efficacy.
Storage
Store below 30°C, protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms may include confusion, blurred vision, abdominal pain. Treatment is symptomatic and supportive; no specific antidote for pantoprazole overdose.
Pregnancy & Lactation
Use in pregnancy only if clearly needed and the potential benefits outweigh the risks. Excreted in breast milk, use with caution during lactation.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole or any component of the formulation
- Hypersensitivity to substituted benzimidazoles
Drug Interactions
Warfarin
Increased INR and bleeding risk.
Clopidogrel
Potential for reduced antiplatelet effect (clinical significance debated).
Methotrexate
Increased methotrexate levels, especially high doses.
Atazanavir/Nelfinavir
Reduced absorption, decreased antiviral efficacy.
Storage
Store below 30°C, protect from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Symptoms may include confusion, blurred vision, abdominal pain. Treatment is symptomatic and supportive; no specific antidote for pantoprazole overdose.
Pregnancy & Lactation
Use in pregnancy only if clearly needed and the potential benefits outweigh the risks. Excreted in breast milk, use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months when stored as recommended. Reconstituted solution is stable for a limited time.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Expired
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous clinical trials to demonstrate efficacy and safety in various acid-related disorders. Ongoing post-marketing surveillance continues to monitor its use.
Lab Monitoring
- Magnesium levels (for long-term use)
- Liver function tests (in patients with hepatic impairment)
- Vitamin B12 levels (for prolonged use, >3 years)
Doctor Notes
- Ensure proper reconstitution and dilution before administration. Check for solution clarity and particulate matter.
- Monitor patients for magnesium levels during prolonged therapy, especially if concurrent diuretic use is present.
- Consider potential drug interactions, particularly with Warfarin, Methotrexate, and certain antivirals.
Patient Guidelines
- Inform your doctor about all existing medical conditions and medications, including over-the-counter drugs and supplements.
- Do not stop the medication suddenly without consulting your doctor, as symptoms may recur.
- Report any unusual or severe side effects immediately to your healthcare provider.
Missed Dose Advice
If a dose is missed, administer it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume the regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances; use caution when driving or operating machinery until you know how this medicine affects you.
Lifestyle Advice
- Avoid trigger foods that worsen acid reflux (e.g., spicy, fatty foods, caffeine, chocolate).
- Elevate the head of the bed to reduce nighttime reflux and eat meals at least 2-3 hours before bedtime.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.