Hemofol-TR
Generic Name
Tranexamic Acid 200 mg Capsule
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| hemofol tr 200 mg capsule | ৳ 2.36 | ৳ 23.60 |
Description
Overview of the medicine
Tranexamic acid is an antifibrinolytic agent that helps reduce bleeding. It works by inhibiting the breakdown of blood clots. It is used to treat or prevent excessive bleeding in various medical conditions, including heavy menstrual bleeding, nosebleeds, and bleeding after certain surgeries.
Uses & Indications
Dosage
Adults
Typical oral dose for Hemofol-TR 200mg capsule: 200-500 mg, 2 to 4 times daily. For menorrhagia, a common dose is 1-1.5 g (5-7 capsules of 200mg) 3-4 times daily for 3-4 days.
Elderly
Dose adjustment usually not required unless renal impairment is present. Monitor renal function.
Renal_impairment
Dose reduction is necessary. Dosage should be adjusted based on creatinine clearance. For CrCl 30-60 mL/min, 200-500 mg twice daily. For CrCl 10-30 mL/min, 200-500 mg once daily.
How to Take
Take Hemofol-TR capsules orally with a glass of water, with or without food. Swallow the capsule whole; do not crush or chew.
Mechanism of Action
Tranexamic acid competitively inhibits the activation of plasminogen to plasmin. Plasmin is an enzyme that degrades fibrin clots (fibrinolysis), so by inhibiting plasmin, tranexamic acid stabilizes the clots and prevents their premature breakdown, thereby promoting hemostasis and reducing bleeding.
Pharmacokinetics
Onset
Within 1-2 hours for oral forms.
Excretion
Primarily excreted unchanged in the urine via glomerular filtration. About 95% of the dose is excreted within 24 hours.
Half life
Approximately 2-11 hours, depending on renal function and dosage.
Absorption
Rapidly absorbed after oral administration. Bioavailability is approximately 30-50%. Peak plasma concentrations are achieved within 2-3 hours.
Metabolism
Minimally metabolized; less than 5% is metabolized.
Side Effects
Contraindications
- Active intravascular clotting or a history of thrombosis (e.g., DVT, PE, cerebral thrombosis), unless concomitant anticoagulant therapy is used.
- Severe renal impairment (risk of accumulation).
- Subarachnoid hemorrhage (due to risk of cerebral edema and infarction).
- History of convulsions or conditions predisposing to convulsions.
- Hypersensitivity to tranexamic acid or any component of the formulation.
Drug Interactions
Tretinoin (oral)
May potentiate the procoagulant effect of tranexamic acid; caution advised.
Oral Contraceptives/Estrogens
Concomitant use may increase the risk of thrombosis, particularly in women with additional risk factors.
Thrombolytic agents (e.g., alteplase, streptokinase)
Antagonistic effect, as tranexamic acid inhibits fibrinolysis. Avoid concomitant use.
Factor IX complex concentrates/anti-inhibitor coagulant complexes
Increased risk of thrombosis.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, orthostatic hypotension, dizziness, headache, and convulsions. Management includes supportive care, gastric lavage if recent ingestion, and symptomatic treatment. Hemodialysis can remove tranexamic acid from the blood.
Pregnancy & Lactation
Pregnancy Category B. Tranexamic acid crosses the placenta. Use in pregnancy only if clearly needed and the potential benefits outweigh the potential risks to the fetus. It is excreted in breast milk in small amounts; use with caution during lactation.
Side Effects
Contraindications
- Active intravascular clotting or a history of thrombosis (e.g., DVT, PE, cerebral thrombosis), unless concomitant anticoagulant therapy is used.
- Severe renal impairment (risk of accumulation).
- Subarachnoid hemorrhage (due to risk of cerebral edema and infarction).
- History of convulsions or conditions predisposing to convulsions.
- Hypersensitivity to tranexamic acid or any component of the formulation.
Drug Interactions
Tretinoin (oral)
May potentiate the procoagulant effect of tranexamic acid; caution advised.
Oral Contraceptives/Estrogens
Concomitant use may increase the risk of thrombosis, particularly in women with additional risk factors.
Thrombolytic agents (e.g., alteplase, streptokinase)
Antagonistic effect, as tranexamic acid inhibits fibrinolysis. Avoid concomitant use.
Factor IX complex concentrates/anti-inhibitor coagulant complexes
Increased risk of thrombosis.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, diarrhea, orthostatic hypotension, dizziness, headache, and convulsions. Management includes supportive care, gastric lavage if recent ingestion, and symptomatic treatment. Hemodialysis can remove tranexamic acid from the blood.
Pregnancy & Lactation
Pregnancy Category B. Tranexamic acid crosses the placenta. Use in pregnancy only if clearly needed and the potential benefits outweigh the potential risks to the fetus. It is excreted in breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date, as specified on the packaging.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies (e.g., DGDA/FDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Tranexamic acid has been extensively studied in various clinical trials, including large-scale trials like CRASH-2 and WOMAN trial, demonstrating its efficacy in reducing mortality from bleeding after trauma and postpartum hemorrhage, respectively.
Lab Monitoring
- Periodic ophthalmic examination (slit lamp, visual acuity, color vision) for long-term use (longer than a few months).
- Renal function tests (serum creatinine, BUN) in patients with impaired renal function or elderly patients.
- Coagulation parameters (PT, aPTT, fibrinogen levels) if monitoring for bleeding disorders.
Doctor Notes
- Carefully assess patient's risk factors for thrombosis (e.g., history of DVT/PE, concurrent estrogen use) before prescribing.
- Monitor renal function, especially in elderly patients or those with pre-existing renal impairment, and adjust dosage accordingly.
- Advise patients to immediately report any signs of a blood clot or changes in vision.
- Not recommended for routine prophylactic use in major surgical procedures unless specifically indicated for high-risk bleeding.
Patient Guidelines
- Do not exceed the recommended dose. Taking more than prescribed can increase the risk of side effects.
- Report any signs of thrombosis immediately (e.g., pain or swelling in a leg, chest pain, sudden shortness of breath, unexplained vision changes).
- Consult your doctor if you experience severe headaches or any visual disturbances.
- If you are taking birth control pills, discuss the risks of blood clots with your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Hemofol-TR may cause dizziness or visual disturbances (e.g., impaired color vision). If you experience these side effects, avoid driving or operating machinery.
Lifestyle Advice
- Maintain good hydration.
- Avoid activities that might cause excessive bleeding if you are susceptible.
- Inform your doctor about all medications, supplements, and herbal products you are taking.
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