Hemosol-B
Generic Name
Hemodialysis Solution, Bicarbonate-Based
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| hemosol b dialysis solution | ৳ 382.00 | N/A |
Description
Overview of the medicine
Hemosol-B Dialysis Solution is a sterile, non-pyrogenic solution used for hemodialysis procedures to remove waste products and excess fluid from the blood in patients with kidney failure, while maintaining electrolyte and acid-base balance. It is a bicarbonate-based solution.
Uses & Indications
Dosage
Adults
Individualized based on patient's specific needs, dialysis prescription, and clinical status. Typically 3-4 hours, 3 times a week, but can vary.
Elderly
No specific dose adjustment beyond individual patient needs. Dosage is determined by the physician based on patient's condition.
Renal_impairment
Primary treatment for end-stage renal disease; dosage is part of the overall dialysis prescription.
How to Take
For use in hemodialysis machines. Requires proper mixing with acid concentrate (if applicable) and sterile connection to the dialyzer and patient's bloodlines. Administered by trained healthcare professionals.
Mechanism of Action
Hemodialysis solutions work by diffusion and ultrafiltration across a semipermeable membrane (dialyzer). Waste products (urea, creatinine, excess electrolytes) move from the patient's blood to the dialysis solution, while essential electrolytes in the solution move into the blood as needed. Bicarbonate in the solution helps to correct metabolic acidosis.
Pharmacokinetics
Onset
Immediate upon initiation of dialysis session.
Excretion
Excess solution components and waste are removed via the dialyzer.
Half life
Not applicable for a solution used ex-vivo.
Absorption
Not absorbed systemically; components exchange across dialyzer membrane.
Metabolism
Not metabolized; components are either exchanged or remain in solution.
Side Effects
Contraindications
- None specific to the solution itself when used correctly; contraindications are generally for the hemodialysis procedure (e.g., severe coagulopathy, hemodynamic instability, lack of vascular access).
Drug Interactions
Dialyzable drugs
No direct drug interactions with the dialysis solution itself, as it is used ex-vivo. However, certain medications may be dialyzable and require dose adjustments (e.g., some antibiotics, antihypertensives). The dialysis prescription aims to maintain optimal drug levels.
Storage
Store at room temperature (20-25°C), protect from freezing and excessive heat. Do not use if solution is cloudy, discolored, or contains particulates.
Overdose
Over-dialysis or inappropriate solution composition can lead to severe electrolyte imbalances (e.g., hyperkalemia, hypokalemia), fluid shifts, hypotension, or hypertension. Management involves immediate cessation of dialysis, correction of imbalances, and supportive care.
Pregnancy & Lactation
Hemodialysis is often life-sustaining for pregnant and lactating women with renal failure. The decision to continue dialysis with appropriate solutions is made by a physician after considering the risks and benefits to both mother and fetus/infant.
Side Effects
Contraindications
- None specific to the solution itself when used correctly; contraindications are generally for the hemodialysis procedure (e.g., severe coagulopathy, hemodynamic instability, lack of vascular access).
Drug Interactions
Dialyzable drugs
No direct drug interactions with the dialysis solution itself, as it is used ex-vivo. However, certain medications may be dialyzable and require dose adjustments (e.g., some antibiotics, antihypertensives). The dialysis prescription aims to maintain optimal drug levels.
Storage
Store at room temperature (20-25°C), protect from freezing and excessive heat. Do not use if solution is cloudy, discolored, or contains particulates.
Overdose
Over-dialysis or inappropriate solution composition can lead to severe electrolyte imbalances (e.g., hyperkalemia, hypokalemia), fluid shifts, hypotension, or hypertension. Management involves immediate cessation of dialysis, correction of imbalances, and supportive care.
Pregnancy & Lactation
Hemodialysis is often life-sustaining for pregnant and lactating women with renal failure. The decision to continue dialysis with appropriate solutions is made by a physician after considering the risks and benefits to both mother and fetus/infant.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years when stored unopened under specified conditions. Refer to product label for exact dates.
Availability
Hospitals, Dialysis Centers, Specialty Pharmacies
Approval Status
Approved by relevant health authorities (e.g., DGDA)
Patent Status
Generic / Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical use has established efficacy and safety. Specific trials for Hemosol-B would focus on bioequivalence to other solutions or specific patient populations.
Lab Monitoring
- Pre- and post-dialysis electrolytes (Na, K, Ca, Mg, Cl, Bicarbonate)
- BUN
- Creatinine
- Glucose
- Acid-base status
- Blood pressure
- Weight
- Hematocrit/Hemoglobin
Doctor Notes
- Ensure correct concentrate ratios for two-part systems. Monitor patient's vital signs and electrolyte levels closely during and after dialysis. Adjust dialysis prescription as per clinical need.
- Always use sterile technique during preparation and administration.
Patient Guidelines
- Adhere strictly to the dialysis schedule.
- Report any adverse effects or discomfort immediately.
- Maintain prescribed dietary and fluid restrictions.
- Attend all scheduled follow-up appointments.
Missed Dose Advice
Missing a dialysis session can be life-threatening. Patients should immediately contact their healthcare provider or dialysis center if a session is missed or cannot be attended.
Driving Precautions
Patients may experience fatigue or hypotension post-dialysis; caution is advised when driving or operating machinery immediately after a session.
Lifestyle Advice
- Maintain a healthy diet as advised by a dietitian.
- Manage fluid intake carefully.
- Engage in light physical activity if medically permitted.
- Avoid smoking and excessive alcohol.
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