Hemotrax
Generic Name
Ferrous Bisglycinate & Folic Acid
Manufacturer
MediCare Pharma Ltd.
Country
Bangladesh
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Description
Overview of the medicine
Hemotrax is a combination of Ferrous Bisglycinate and Folic Acid, primarily used to treat and prevent iron deficiency anemia and megaloblastic anemia, especially during pregnancy and lactation. Ferrous Bisglycinate is a chelated form of iron that is well-absorbed and causes fewer gastrointestinal side effects compared to other iron salts. Folic Acid is essential for DNA synthesis and red blood cell formation.
Uses & Indications
Dosage
Adults
Usually 1 tablet once daily, or as directed by the physician.
Elderly
Same as adult dosage, but caution should be exercised in patients with underlying comorbidities.
Renal_impairment
No specific dose adjustment required, but monitor iron levels in severe impairment.
How to Take
Hemotrax tablets should be swallowed whole with water, preferably after meals to minimize gastrointestinal upset. Do not chew or crush the tablet.
Mechanism of Action
Ferrous Bisglycinate provides elemental iron, a crucial component of hemoglobin, myoglobin, and several enzymes. It facilitates oxygen transport and energy metabolism. Folic Acid, a B vitamin, is converted to tetrahydrofolate, a coenzyme vital for nucleic acid synthesis (DNA and RNA), amino acid metabolism, and erythrocyte maturation. The combination ensures adequate red blood cell production and function.
Pharmacokinetics
Onset
Improved symptoms within weeks, full hematological response in 4-8 weeks.
Excretion
Iron is primarily excreted via feces, with small amounts lost through sweat, urine, and sloughed cells. Folic acid and its metabolites are excreted mainly in urine and feces.
Half life
Iron half-life is complex due to storage and recycling. Folic acid plasma half-life is approximately 3-6 hours.
Absorption
Ferrous Bisglycinate is highly bioavailable and efficiently absorbed from the gastrointestinal tract, with absorption enhanced by vitamin C. Folic acid is rapidly absorbed from the small intestine.
Metabolism
Iron is not metabolized in the traditional sense but incorporated into various proteins. Folic acid is metabolized in the liver and active tissues to tetrahydrofolate.
Side Effects
Contraindications
- •Patients with hypersensitivity to any component of the formulation.
- •Hemochromatosis (iron overload disorder).
- •Hemolytic anemia (unless iron deficiency also present).
- •Repeated blood transfusions.
Drug Interactions
Antacids
May reduce iron absorption; separate administration by at least 2 hours.
Levothyroxine
Iron can impair levothyroxine absorption; administer at least 4 hours apart.
Bisphosphonates
Iron may reduce their absorption; take iron at least 30 minutes after bisphosphonates.
Tetracyclines & Quinolones
Iron may reduce absorption of these antibiotics; separate administration by at least 2-3 hours.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture.
Overdose
Symptoms of iron overdose include severe nausea, vomiting, abdominal pain, diarrhea, lethargy, and sometimes shock. Folic acid overdose is generally non-toxic. In case of iron overdose, seek immediate medical attention. Treatment may involve gastric lavage, chelating agents (e.g., deferoxamine) and supportive care.
Pregnancy & Lactation
Hemotrax is often indicated and considered safe during pregnancy and lactation for the treatment and prevention of iron and folic acid deficiencies, as these needs are increased during these periods. Consult a physician.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Available in pharmacies and hospitals nationwide
Approval Status
Approved by DGDA
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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