Hemotrax
Generic Name
Iron Dextran
Manufacturer
Hypothetical Pharma Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| hemotrax 500 mg injection | ৳ 70.00 | N/A |
Description
Overview of the medicine
Hemotrax 500 mg Injection is an iron preparation used to treat iron deficiency anemia in patients who cannot tolerate or respond to oral iron supplementation.
Uses & Indications
Dosage
Adults
Dosage is individualized based on total iron deficit. Typically 100-200 mg elemental iron daily or every other day, up to a total cumulative dose determined by body weight and hemoglobin levels.
Elderly
Similar to adult dosage, but caution with cardiovascular status. Start with a lower dose.
Renal_impairment
No specific dose adjustment for mild to moderate impairment, but careful monitoring is required. Avoid in severe unmanaged renal failure without consultation.
How to Take
For IV infusion, dilute the calculated dose in 250-1000 mL of 0.9% sodium chloride and infuse slowly over 1-6 hours. For IM injection, administer deep into the upper outer quadrant of the buttock using the Z-track technique.
Mechanism of Action
Iron dextran replenishes iron stores, which are necessary for the formation of hemoglobin, myoglobin, and other iron-containing enzymes. It is incorporated into the erythroid precursor cells to form new red blood cells.
Pharmacokinetics
Onset
Onset of hemoglobin increase usually within 1-2 weeks.
Excretion
Mainly through the reticuloendothelial system; minimal urinary excretion.
Half life
Variable, typically 3-5 days for the iron component once incorporated into transferrin.
Absorption
After intramuscular or intravenous administration, iron dextran is absorbed and then dissociated into elemental iron and dextran in the reticuloendothelial system. The rate of dissociation varies.
Metabolism
Iron is metabolized and incorporated into hemoglobin; dextran is metabolized or excreted.
Side Effects
Contraindications
- Hypersensitivity to iron dextran or any component.
- All anemias not caused by iron deficiency.
- Iron overload (e.g., hemochromatosis, hemosiderosis).
- Acute infective processes.
Drug Interactions
ACE Inhibitors
Increased risk of systemic reactions, especially with high doses.
Chloramphenicol
May delay response to iron therapy by interfering with erythropoiesis.
Oral Iron Preparations
Reduced absorption of oral iron if given concurrently.
Storage
Store below 30°C. Do not freeze. Protect from light.
Overdose
Overdose can lead to hemosiderosis. Treatment involves chelating agents (e.g., deferoxamine) and supportive measures.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed. Iron appears in breast milk, but risk to nursing infant is low.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies, Hospitals
Approval Status
Approved by relevant health authorities (e.g., FDA, DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of iron dextran for iron deficiency anemia.
Lab Monitoring
- Hemoglobin and Hematocrit levels
- Serum Ferritin
- Transferrin saturation (TSAT)
Doctor Notes
- Administer a test dose before the full therapeutic dose to assess for hypersensitivity.
- Monitor vital signs during and after administration.
- Educate patients on potential injection site staining.
Patient Guidelines
- Report any allergic reactions immediately.
- Do not self-administer.
- Keep all appointments for injections and follow-up tests.
Missed Dose Advice
Contact your doctor or nurse immediately if you miss an appointment for an injection.
Driving Precautions
May cause dizziness; avoid driving or operating heavy machinery until you know how it affects you.
Lifestyle Advice
- Maintain a balanced diet.
- Stay hydrated.
- Regular exercise as advised by your doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.