Hemroid
Generic Name
Diosmin + Hesperidin (Micronized Purified Flavonoid Fraction)
Manufacturer
Hypothetical Pharma Co. Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| hemroid 500 mg capsule | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Hemroid 500 mg capsule is an oral medication containing a micronized purified flavonoid fraction (Diosmin and Hesperidin) used for the treatment of chronic venous insufficiency and hemorrhoidal disease. It works by improving venous tone and lymphatic drainage, reducing capillary hyperpermeability.
Uses & Indications
Dosage
Adults
For acute hemorrhoids: 3 capsules twice daily for 4 days, then 2 capsules twice daily for 3 days. For chronic venous insufficiency/chronic hemorrhoids: 1 capsule twice daily.
Elderly
No specific dosage adjustment required, but caution is advised.
Renal_impairment
No specific dosage adjustment data available; use with caution.
How to Take
Administer orally, usually with meals.
Mechanism of Action
It prolongs the vasoconstrictor effect of noradrenaline on the venous wall, increasing venous tone. It also reduces capillary permeability and improves lymphatic drainage, thereby reducing edema and inflammation associated with venous diseases.
Pharmacokinetics
Onset
Within 1-2 hours for some effects, full therapeutic effect may take days to weeks.
Excretion
Mainly via feces (about 80%), and some via urine (about 14%).
Half life
Approximately 11 hours for diosmin metabolites.
Absorption
Rapidly absorbed after oral administration, extensively metabolized.
Metabolism
Extensively metabolized in the liver to phenolic acids, predominantly by intestinal microflora.
Side Effects
Contraindications
- Hypersensitivity to Diosmin, Hesperidin, or any components of the formulation.
- Lactation (relative contraindication due to lack of data).
Drug Interactions
Anticoagulants
Potential to enhance the effect of anticoagulants like warfarin, though clinical significance is generally low.
Enzyme Inhibitors/Inducers
May interact with CYP450 enzymes; monitor for altered effects of co-administered drugs.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms are generally mild and may include gastrointestinal disturbances. Management is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy: Limited human data. Use only if clearly needed and potential benefits outweigh risks. Lactation: Excretion into breast milk is unknown. Avoid during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to Diosmin, Hesperidin, or any components of the formulation.
- Lactation (relative contraindication due to lack of data).
Drug Interactions
Anticoagulants
Potential to enhance the effect of anticoagulants like warfarin, though clinical significance is generally low.
Enzyme Inhibitors/Inducers
May interact with CYP450 enzymes; monitor for altered effects of co-administered drugs.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Overdose symptoms are generally mild and may include gastrointestinal disturbances. Management is symptomatic and supportive.
Pregnancy & Lactation
Pregnancy: Limited human data. Use only if clearly needed and potential benefits outweigh risks. Lactation: Excretion into breast milk is unknown. Avoid during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture.
Availability
Pharmacies, drugstores, online
Approval Status
Approved by DGDA/FDA equivalent in many countries for venous insufficiency and hemorrhoids
Patent Status
Generic available, original patent expired
Clinical Trials
Numerous clinical trials have demonstrated the efficacy of MPFF (Diosmin + Hesperidin) in treating chronic venous insufficiency and hemorrhoids.
Lab Monitoring
- No specific routine lab monitoring is required.
- Monitor for signs of bleeding if co-administered with anticoagulants.
Doctor Notes
- Advise patients on lifestyle modifications for venous conditions.
- Counsel on proper dosage, especially for acute hemorrhoidal crises.
- Monitor for potential drug interactions, though rare.
- Emphasize consistent use for chronic conditions.
Patient Guidelines
- Take exactly as prescribed by your doctor.
- Swallow the capsule whole, do not chew or crush.
- Take with meals to minimize gastrointestinal discomfort.
- For hemorrhoids, ensure adequate fiber intake and hydration.
- Report any unusual side effects to your doctor.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.
Driving Precautions
This medication is not expected to affect the ability to drive or operate machinery. However, if you experience dizziness, avoid such activities.
Lifestyle Advice
- Elevate legs, avoid prolonged standing/sitting.
- Maintain a healthy weight.
- Regular exercise, especially walking.
- Avoid straining during bowel movements.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.