Henxit
Generic Name
Clonazepam
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| henxit 05 mg tablet | ৳ 3.50 | N/A |
Description
Overview of the medicine
Henxit 0.5 mg Tablet contains Clonazepam, a benzodiazepine, primarily used to treat various seizure disorders including Lennox-Gastaut syndrome, akinetic and myoclonic seizures. It is also used for panic disorder and sometimes for restless legs syndrome.
Uses & Indications
Dosage
Adults
Initial dose for seizure disorders: 0.5 mg three times daily. May be increased by 0.5 mg to 1 mg every 3 days until seizure control is achieved or side effects preclude further increase. Max: 20 mg/day. For panic disorder: Initial 0.25 mg twice daily, increased to 1 mg/day after 3 days. Max: 4 mg/day.
Elderly
Lower initial doses (e.g., 0.25 mg once daily) and slower titration recommended due to increased sensitivity and risk of adverse effects.
Renal_impairment
No specific dosage adjustment recommended for mild to moderate renal impairment, but caution is advised. Not recommended in severe impairment.
How to Take
Take orally with or without food. Swallow the tablet whole with water. Do not crush or chew.
Mechanism of Action
Clonazepam enhances the effect of gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the central nervous system. It binds to benzodiazepine receptors on GABA-A receptor complexes, which leads to an increased influx of chloride ions into the neuron, causing hyperpolarization and reducing neuronal excitability.
Pharmacokinetics
Onset
Anticonvulsant effect: 20-60 minutes (oral).
Excretion
Excreted mainly in the urine as metabolites, with a small amount excreted unchanged.
Half life
Plasma elimination half-life is 18-50 hours.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract. Peak plasma concentrations are reached within 1-4 hours.
Metabolism
Extensively metabolized in the liver, primarily by nitroreduction, to 7-amino-clonazepam, which is then acetylated. CYP3A4 is involved.
Side Effects
Contraindications
- Acute narrow-angle glaucoma
- Severe respiratory insufficiency
- Severe hepatic impairment
- Myasthenia gravis
- Hypersensitivity to clonazepam or other benzodiazepines
Drug Interactions
Opioids
Increased risk of profound sedation, respiratory depression, coma, and death.
CYP3A4 inducers (e.g., Rifampin)
May decrease clonazepam plasma concentrations.
Alcohol and other CNS depressants
Additive CNS depressant effects leading to increased sedation, respiratory depression.
Antiepileptics (e.g., Phenytoin, Carbamazepine)
May alter clonazepam levels or increase CNS depression.
CYP3A4 inhibitors (e.g., Ketoconazole, Ritonavir)
May increase clonazepam plasma concentrations.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include somnolence, confusion, impaired coordination, diminished reflexes, and coma. Management involves supportive care, maintaining airway, and monitoring vital signs. Flumazenil may be used to reverse benzodiazepine effects but should be used with caution, especially in patients with seizure disorders.
Pregnancy & Lactation
Pregnancy Category D. May cause fetal harm. Avoid during pregnancy unless potential benefits outweigh risks. Excreted in breast milk, not recommended during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by FDA and DGDA
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensively studied in clinical trials for its efficacy in various seizure disorders and panic disorder, demonstrating significant reduction in seizure frequency and panic attack severity compared to placebo.
Lab Monitoring
- Regular monitoring of blood counts and liver function tests recommended during long-term therapy.
- Monitor drug levels if toxicity or non-response is suspected.
Doctor Notes
- Always initiate clonazepam at the lowest effective dose and titrate slowly.
- Educate patients on the risks of dependence and withdrawal.
- Counsel patients on avoiding alcohol and driving while on this medication.
Patient Guidelines
- Do not stop taking this medicine abruptly, as it may lead to withdrawal symptoms.
- Avoid alcohol and other CNS depressants while on this medication.
- Report any unusual mood or behavior changes to your doctor.
- This medicine may cause drowsiness; avoid driving or operating heavy machinery until you know how it affects you.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.
Driving Precautions
Clonazepam can cause drowsiness, dizziness, and impaired coordination, which may affect your ability to drive or operate machinery. Avoid such activities until you are certain the medication does not impair your abilities.
Lifestyle Advice
- Maintain a regular sleep schedule.
- Practice stress-reduction techniques.
- Avoid caffeine and stimulants, especially in the evening.
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.