Administer by intravenous (IV) injection or continuous IV infusion, or by deep subcutaneous (SC) injection. Do not administer intramuscularly (IM) due to risk of hematoma.

Heparin exerts its anticoagulant effect by binding to antithrombin III (AT III) and increasing its activity by approximately 1000-fold. This enhanced AT III then inactivates thrombin (Factor IIa) and Factor Xa, preventing the formation of fibrin and subsequently blood clots.

• •Active major bleeding
• •History of Heparin-induced thrombocytopenia (HIT)
• •Severe uncontrolled hypertension
• •Recent major surgery (especially brain, spinal cord, eye)
• •Bleeding disorders (e.g., hemophilia)

Store at controlled room temperature (20-25°C), protect from freezing and excessive heat. Do not refrigerate. Once opened, use within 28 days.

Overdose of Heparon can lead to severe bleeding. The anticoagulant effect can be rapidly neutralized by the intravenous administration of Protamine Sulfate. Dosage of protamine sulfate depends on the amount of heparin given and time elapsed.

Pregnancy Category C. Heparin does not cross the placenta and is generally considered safe for use during pregnancy when clinically indicated. It is not excreted into breast milk and is considered safe for breastfeeding mothers.