Herpigel
Generic Name
Aciclovir Ophthalmic Gel
Manufacturer
XYZ Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| herpigel 015 eye gel | ৳ 200.00 | N/A |
Description
Overview of the medicine
Herpigel is an antiviral eye gel containing Aciclovir, used for the treatment of herpes simplex virus infections of the eye, particularly herpetic keratitis.
Uses & Indications
Dosage
Adults
Apply a 1 cm ribbon of the eye gel into the lower conjunctival sac 5 times daily, approximately every 4 hours, for 7 to 10 days. Treatment should be continued for at least 3 days after healing is complete.
Elderly
No specific dosage adjustment is recommended for elderly patients.
Renal_impairment
No dosage adjustment is necessary for patients with renal impairment, as systemic absorption from ophthalmic administration is minimal.
How to Take
For ophthalmic use only. Wash hands thoroughly before and after application. Tilt your head back, pull down the lower eyelid to form a pocket, and apply a thin ribbon (about 1 cm) of the gel into the pocket. Close your eye gently for 1-2 minutes. Avoid touching the tip of the tube to the eye or any other surface to prevent contamination.
Mechanism of Action
Aciclovir is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus (HSV) types 1 and 2 and varicella-zoster virus (VZV). It is phosphorylated to its active triphosphate form by viral thymidine kinase, which then inhibits viral DNA replication by competitive inhibition of viral DNA polymerase and chain termination.
Pharmacokinetics
Onset
Local antiviral action begins rapidly, with clinical improvement typically observed within a few days of initiation of therapy.
Excretion
Excretion is primarily renal (if systemically absorbed). Ocular elimination occurs through the tear film and corneal turnover.
Half life
Systemic half-life is approximately 2.5-3.3 hours if significant systemic absorption occurs (which is minimal from ocular route). Ocular elimination is primarily via tear film turnover.
Absorption
Aciclovir is poorly absorbed systemically from ocular administration. After ophthalmic application, it penetrates the cornea and achieves therapeutic concentrations in the aqueous humor.
Metabolism
Minimal metabolism occurs after ocular application. Systemically, it is metabolized to 9-carboxymethoxymethylguanine.
Side Effects
Contraindications
- Hypersensitivity to Aciclovir, Valaciclovir, or any components of the formulation.
Drug Interactions
Systemic drugs
Due to minimal systemic absorption, clinically significant drug interactions are unlikely with ophthalmic Aciclovir.
Storage
Store below 25°C. Do not freeze. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose following ocular administration is highly unlikely. If accidentally ingested, symptoms may include nausea, vomiting, headache, and confusion; symptomatic and supportive measures should be taken.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Limited data suggest minimal systemic absorption, thus low risk. Excretion into breast milk is minimal following ophthalmic use, but caution should be exercised. Consult your doctor.
Side Effects
Contraindications
- Hypersensitivity to Aciclovir, Valaciclovir, or any components of the formulation.
Drug Interactions
Systemic drugs
Due to minimal systemic absorption, clinically significant drug interactions are unlikely with ophthalmic Aciclovir.
Storage
Store below 25°C. Do not freeze. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose following ocular administration is highly unlikely. If accidentally ingested, symptoms may include nausea, vomiting, headache, and confusion; symptomatic and supportive measures should be taken.
Pregnancy & Lactation
Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Limited data suggest minimal systemic absorption, thus low risk. Excretion into breast milk is minimal following ophthalmic use, but caution should be exercised. Consult your doctor.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24 months (unopened). Discard 28 days after opening.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Numerous clinical trials have established the efficacy and safety of Aciclovir for the treatment of herpes simplex virus keratitis. Studies show rapid healing of dendritic ulcers with minimal adverse effects.
Lab Monitoring
- No routine laboratory monitoring is required for ophthalmic Aciclovir.
Doctor Notes
- Emphasize strict adherence to the dosage regimen and duration of treatment to ensure complete viral suppression and prevent recurrence.
- Educate patients on proper application technique and hygiene to minimize contamination.
- Monitor for signs of secondary bacterial infection, which may require additional treatment.
Patient Guidelines
- Do not wear contact lenses during treatment for ocular herpes.
- Discard the tube 28 days after opening, even if some gel remains.
- Do not share this medicine with others.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one.
Driving Precautions
This medicine may cause transient blurred vision immediately after application. Avoid driving or operating machinery until your vision clears.
Lifestyle Advice
- Maintain good eye hygiene to prevent further irritation or infection.
- Avoid rubbing your eyes.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.