Hexinor
Generic Name
Trihexyphenidyl Hydrochloride
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| hexinor 2 mg tablet | ৳ 5.50 | ৳ 55.00 |
Description
Overview of the medicine
Hexinor 2 mg Tablet contains Trihexyphenidyl Hydrochloride, an anticholinergic medication used to treat symptoms of Parkinson's disease and drug-induced extrapyramidal symptoms.
Uses & Indications
Dosage
Adults
For Parkinsonism, initially 1 mg daily, increased by 2 mg every 3 to 5 days until optimal response. Maintenance dose: 6-10 mg daily in 3-4 divided doses, up to 15 mg/day. For drug-induced extrapyramidal disorders, 5-15 mg daily in divided doses.
Elderly
Start with a lower dose (e.g., 0.5 mg daily) and titrate carefully due to increased susceptibility to side effects.
Renal_impairment
Use with caution; dose reduction may be necessary. Specific guidelines often not well-defined, monitor for side effects.
How to Take
Take with or after meals to minimize gastrointestinal irritation. The total daily dose should be divided into 3 or 4 doses.
Mechanism of Action
Trihexyphenidyl acts by blocking central cholinergic receptors, thereby reducing the excessive cholinergic activity that contributes to symptoms like tremor and rigidity in Parkinson's disease and drug-induced extrapyramidal disorders.
Pharmacokinetics
Onset
Onset of action typically within 1 hour.
Excretion
Excreted primarily in the urine as metabolites and unchanged drug.
Half life
Half-life is approximately 6-10 hours.
Absorption
Well absorbed from the gastrointestinal tract.
Metabolism
Metabolized in the liver.
Side Effects
Contraindications
- Angle-closure glaucoma
- Gastrointestinal obstruction
- Urinary obstruction (e.g., prostatic hypertrophy)
- Myasthenia gravis
- Hypersensitivity to Trihexyphenidyl
Drug Interactions
Digoxin
May increase digoxin absorption.
Levodopa
May reduce the therapeutic effect of levodopa.
CNS Depressants
May potentiate the sedative effects.
Other Anticholinergics
Increased risk of anticholinergic side effects.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms include CNS stimulation followed by depression, circulatory collapse, respiratory depression, paralysis, coma, hyperpyrexia. Management involves symptomatic and supportive care, gastric lavage, activated charcoal, and in severe cases, physostigmine may be considered.
Pregnancy & Lactation
Pregnancy Category C. Use only if the potential benefit outweighs the potential risk to the fetus. Excreted in breast milk, avoid during breastfeeding if possible.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies (e.g., DGDA)
Patent Status
Off-patent
WHO Essential Medicine
YesClinical Trials
Extensive clinical experience since its introduction in the 1940s. No recent major trials for new indications.
Lab Monitoring
- Intraocular pressure (for glaucoma risk)
- Renal and hepatic function (in patients with impairment)
Doctor Notes
- Monitor for anticholinergic side effects, especially in elderly patients.
- Caution in patients with cardiac disease, hypertension, or hepatic/renal impairment.
- Advise gradual withdrawal to avoid rebound symptoms.
Patient Guidelines
- Do not stop taking this medication abruptly.
- Avoid alcohol and other CNS depressants.
- Report any changes in vision or difficulty urinating.
- Be aware of potential for heat intolerance.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not double the dose to catch up.
Driving Precautions
May cause dizziness, blurred vision, or drowsiness. Avoid driving or operating heavy machinery until you know how this medicine affects you.
Lifestyle Advice
- Maintain adequate hydration to combat dry mouth.
- Regular exercise as advised by your doctor.
- Avoid situations where overheating may occur.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.