Histaphen
Generic Name
Chlorpheniramine Maleate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| histaphen 5 mg oral solution | ৳ 8.60 | N/A |
Description
Overview of the medicine
Histaphen 5 mg Oral Solution contains Chlorpheniramine Maleate, a first-generation antihistamine used to relieve symptoms of allergies such as sneezing, runny nose, watery eyes, and itching.
Uses & Indications
Dosage
Adults
5 mg (5 ml) every 4 to 6 hours, not to exceed 30 mg (30 ml) in 24 hours.
Elderly
Lower initial doses (e.g., 2.5 mg or 2.5 ml) are recommended due to increased sensitivity to anticholinergic side effects and sedation.
Renal_impairment
Use with caution; dose reduction may be necessary. Specific guidelines vary.
How to Take
Take orally, with or without food. Use a measuring spoon or cup for accurate dosing.
Mechanism of Action
Chlorpheniramine Maleate acts as an antagonist at H1-histamine receptors, thereby blocking the action of histamine, which is responsible for allergic symptoms.
Pharmacokinetics
Onset
Onset of action typically occurs within 30-60 minutes.
Excretion
Excreted primarily in the urine, both as unchanged drug and metabolites.
Half life
Plasma half-life ranges from 12 to 43 hours, varying significantly between individuals.
Absorption
Well absorbed from the gastrointestinal tract after oral administration. Peak plasma concentrations are achieved within 2-6 hours.
Metabolism
Extensively metabolized in the liver by demethylation and hydroxylation.
Side Effects
Contraindications
- •Known hypersensitivity to chlorpheniramine or any component of the formulation
- •Patients taking monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping MAOI therapy
- •Newborns or premature infants
- •Severe lower respiratory tract symptoms, including asthma attacks
Drug Interactions
Monoamine Oxidase Inhibitors (MAOIs)
Prolongs and intensifies the anticholinergic effects of antihistamines.
CNS Depressants (e.g., alcohol, benzodiazepines, opioids)
Increased sedation and central nervous system depression.
Anticholinergics (e.g., tricyclic antidepressants, atropine)
Potentiated anticholinergic effects such as dry mouth, urinary retention.
Storage
Store below 30°C, protected from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include severe drowsiness, dizziness, incoordination, dry mouth, flushed skin, dilated pupils, fever, hallucinations, tremors, and seizures. In severe cases, respiratory depression and cardiovascular collapse may occur. Treatment is symptomatic and supportive, including gastric lavage or activated charcoal, and management of symptoms.
Pregnancy & Lactation
Pregnancy Category B. Use with caution during pregnancy, especially in the third trimester. Not recommended during lactation as it can be excreted in breast milk and may cause drowsiness in the infant and reduce milk supply.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
2-3 years, as indicated on the packaging.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by regulatory bodies (e.g., DGDA, FDA)
Patent Status
Generic; patent expired
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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