Oral. May be taken with or without food. To reduce stomach upset, take with food or milk.

Chlorpheniramine Maleate is a competitive antagonist of H1-histamine receptors. It binds to H1 receptors and prevents histamine from binding, thereby inhibiting the effects of histamine such as vasodilation, increased capillary permeability, itching, and bronchoconstriction.

• •Hypersensitivity to chlorpheniramine or any component of the formulation
• •Acute asthma attacks
• •Narrow-angle glaucoma
• •Prostatic hypertrophy with urinary retention
• •Newborns or premature infants

Store below 30°C in a dry place, protected from light and moisture. Keep out of reach of children.

Symptoms include severe drowsiness, coma, convulsions, hallucinations, dilated pupils, dry mouth, flushed skin, fever. Management involves supportive care, gastric lavage/activated charcoal if recent ingestion, and managing symptoms (e.g., benzodiazepines for seizures, cooling for hyperthermia).

Pregnancy Category B. Generally considered safe, but use only if clearly needed. Avoid during third trimester due to potential for withdrawal symptoms in newborn. Not recommended during breastfeeding as it can pass into breast milk and may cause drowsiness in the infant and reduce milk supply.