Hydeca
Generic Name
Hydrocortisone Sodium Succinate
Manufacturer
PharmaCo Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| hydeca 50 mg injection | ৳ 125.00 | N/A |
Description
Overview of the medicine
Hydeca 50 mg Injection contains Hydrocortisone Sodium Succinate, a synthetic glucocorticoid. It is used for its potent anti-inflammatory and immunosuppressive properties.
Uses & Indications
Dosage
Adults
Dosage varies depending on the condition. For acute adrenal insufficiency, 100 mg to 500 mg IV, repeated every 2-10 hours as needed. For other conditions, 50 mg to 100 mg IV/IM, repeated as directed by physician.
Elderly
No specific dosage adjustment for elderly; however, caution is advised due to potential comorbidities and reduced organ function. Start with the lower end of the adult dose range.
Renal_impairment
No specific dosage adjustment is generally required for renal impairment, but clinical monitoring is recommended.
How to Take
Hydeca 50 mg Injection is administered by intravenous (IV) or intramuscular (IM) route. It should be prepared and administered by a healthcare professional.
Mechanism of Action
Hydrocortisone binds to glucocorticoid receptors in target cells, modulating gene expression. This leads to reduced inflammation by inhibiting prostaglandin synthesis, decreasing capillary permeability, and suppressing various immune responses.
Pharmacokinetics
Onset
Within minutes for intravenous administration.
Excretion
Excreted mainly through urine as metabolites.
Half life
Plasma half-life is 1-2 hours; biological half-life is 8-12 hours.
Absorption
Rapidly absorbed after intramuscular (IM) or intravenous (IV) administration.
Metabolism
Primarily metabolized in the liver by 11-beta-hydroxysteroid dehydrogenase and other enzymes.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to hydrocortisone or any component of the formulation
Drug Interactions
NSAIDs
Increased risk of gastrointestinal bleeding/ulceration.
Antidiabetics
May increase blood glucose, requiring adjustment of antidiabetic medication.
Anticoagulants
May alter anticoagulant effect; require dose adjustment.
Diuretics (e.g., Furosemide)
Increased risk of hypokalemia.
CYP3A4 Inhibitors (e.g., Ketoconazole)
May increase hydrocortisone levels.
CYP3A4 Inducers (e.g., Phenytoin, Rifampicin)
May decrease hydrocortisone levels.
Storage
Store below 25°C, protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is rare. Symptoms may include fluid retention, hyperglycemia, and electrolyte imbalance. Treatment is symptomatic and supportive; no specific antidote.
Pregnancy & Lactation
Use in pregnancy only if the potential benefit outweighs the potential risk to the fetus. Hydrocortisone is excreted in breast milk; caution is advised during breastfeeding.
Side Effects
Contraindications
- Systemic fungal infections
- Known hypersensitivity to hydrocortisone or any component of the formulation
Drug Interactions
NSAIDs
Increased risk of gastrointestinal bleeding/ulceration.
Antidiabetics
May increase blood glucose, requiring adjustment of antidiabetic medication.
Anticoagulants
May alter anticoagulant effect; require dose adjustment.
Diuretics (e.g., Furosemide)
Increased risk of hypokalemia.
CYP3A4 Inhibitors (e.g., Ketoconazole)
May increase hydrocortisone levels.
CYP3A4 Inducers (e.g., Phenytoin, Rifampicin)
May decrease hydrocortisone levels.
Storage
Store below 25°C, protected from light and moisture. Do not freeze. Keep out of reach of children.
Overdose
Acute overdose is rare. Symptoms may include fluid retention, hyperglycemia, and electrolyte imbalance. Treatment is symptomatic and supportive; no specific antidote.
Pregnancy & Lactation
Use in pregnancy only if the potential benefit outweighs the potential risk to the fetus. Hydrocortisone is excreted in breast milk; caution is advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2 to 3 years from the date of manufacture when stored correctly. Once reconstituted, stability varies; check product leaflet.
Availability
Available in hospitals and pharmacies
Approval Status
FDA Approved, DGDA Approved
Patent Status
Generic available, Off-patent
WHO Essential Medicine
YesClinical Trials
Hydrocortisone has undergone extensive clinical trials over decades, establishing its efficacy and safety for various indications, particularly in critical care and inflammatory diseases.
Lab Monitoring
- Blood glucose levels
- Electrolyte levels (especially potassium)
- Blood pressure
- Bone mineral density (for long-term use)
Doctor Notes
- For long-term therapy, gradual tapering of the dose is crucial to prevent adrenal insufficiency.
- Monitor patients for signs of infection, especially with high doses or prolonged use.
- Consider bone protection strategies (e.g., calcium/vitamin D) for long-term corticosteroid users.
Patient Guidelines
- Do not stop this medicine abruptly without consulting your doctor, especially if on long-term therapy.
- Report any unusual symptoms like severe stomach pain, unusual bleeding, or vision changes.
- Monitor your blood sugar levels regularly if you are diabetic.
Missed Dose Advice
If a dose is missed, administer it as soon as you remember, unless it is almost time for your next dose. Do not double the dose. Consult your doctor for specific instructions.
Driving Precautions
Generally, Hydeca injection does not impair the ability to drive or operate machinery. However, if you experience mood changes, dizziness, or vision disturbances, avoid these activities.
Lifestyle Advice
- Maintain a healthy diet, possibly with reduced sodium intake to prevent fluid retention.
- Engage in regular, moderate exercise to maintain muscle strength and bone health.
- Ensure adequate calcium and Vitamin D intake, especially during long-term therapy.
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Global Brand Names
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