Iben
Generic Name
Ibuprofen
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
Loading images...
Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| iben 400 mg tablet | ৳ 1.30 | ৳ 13.00 |
Description
Overview of the medicine
Iben 400 mg Tablet contains Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID) used for relieving pain, reducing inflammation, and lowering fever. It works by blocking the body's production of certain natural substances that cause inflammation.
Uses & Indications
Dosage
Adults
Oral: 200-400 mg every 4-6 hours as needed. Maximum dose: 1200 mg/day for OTC use; up to 2400 mg/day for prescription use.
Elderly
Use lowest effective dose for the shortest duration. Monitor for renal and gastrointestinal adverse effects.
Renal_impairment
Use with caution. Dosage adjustment may be required based on severity of impairment. Avoid in severe renal failure.
How to Take
Take orally, preferably with food or milk to minimize gastrointestinal upset. Do not crush or chew the tablet.
Mechanism of Action
Ibuprofen is a non-selective inhibitor of cyclooxygenase (COX-1 and COX-2) enzymes. This inhibition reduces the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Analgesic effect: 30-60 minutes; Antipyretic effect: 1 hour; Anti-inflammatory effect: within 7 days.
Excretion
Excreted rapidly and completely in the urine (approximately 60-90% as metabolites and their conjugates, and 1% as unchanged drug) within 24 hours.
Half life
Approximately 1.8 to 2.5 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract. Peak plasma concentrations are typically achieved within 1 to 2 hours after oral administration.
Metabolism
Extensively metabolized in the liver (primarily via CYP2C9 and CYP2C8) to two inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to ibuprofen or other NSAIDs (e.g., aspirin-induced asthma)
- Active gastrointestinal bleeding or peptic ulcer
- Severe heart failure, severe renal impairment, or severe hepatic impairment
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
ACE inhibitors/Diuretics
Reduced antihypertensive and diuretic effects, increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, lethargy, drowsiness, nystagmus, tinnitus, and headache. More severe cases may involve gastrointestinal bleeding, acute renal failure, coma, metabolic acidosis, and respiratory depression. Management includes gastric lavage, activated charcoal, and supportive treatment.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters), Category D (third trimester) due to risk of premature closure of fetal ductus arteriosus. Avoid use in the third trimester. Use with caution in lactation; small amounts are excreted in breast milk.
Side Effects
Contraindications
- Hypersensitivity to ibuprofen or other NSAIDs (e.g., aspirin-induced asthma)
- Active gastrointestinal bleeding or peptic ulcer
- Severe heart failure, severe renal impairment, or severe hepatic impairment
- Third trimester of pregnancy
- Coronary artery bypass graft (CABG) surgery
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased plasma lithium levels.
Methotrexate
Increased methotrexate toxicity.
ACE inhibitors/Diuretics
Reduced antihypertensive and diuretic effects, increased risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include nausea, vomiting, abdominal pain, lethargy, drowsiness, nystagmus, tinnitus, and headache. More severe cases may involve gastrointestinal bleeding, acute renal failure, coma, metabolic acidosis, and respiratory depression. Management includes gastric lavage, activated charcoal, and supportive treatment.
Pregnancy & Lactation
Pregnancy Category C (first and second trimesters), Category D (third trimester) due to risk of premature closure of fetal ductus arteriosus. Avoid use in the third trimester. Use with caution in lactation; small amounts are excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Generic, Off-patent
WHO Essential Medicine
YesClinical Trials
Ibuprofen has been extensively studied in numerous clinical trials for its efficacy and safety in various pain and inflammatory conditions. Ongoing research continues to explore its applications and long-term effects.
Lab Monitoring
- Complete blood count (CBC) for prolonged use
- Renal function tests (e.g., serum creatinine, BUN) for prolonged use or in patients with risk factors
- Liver function tests (e.g., ALT, AST) for prolonged use
Doctor Notes
- Prescribe the lowest effective dose for the shortest possible duration to minimize risks.
- Monitor gastrointestinal, renal, and cardiovascular risk factors in patients, especially with prolonged use.
- Advise patients to report any signs of gastrointestinal bleeding or cardiovascular symptoms promptly.
Patient Guidelines
- Take with food or milk to reduce stomach upset.
- Do not exceed the recommended dose or duration of use.
- Avoid alcohol while taking this medicine.
- Inform your doctor about all other medications you are taking.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
May cause dizziness, drowsiness, or visual disturbances. Exercise caution when driving or operating machinery until you know how the medicine affects you.
Lifestyle Advice
- Maintain adequate hydration.
- For chronic pain, consider combining with non-pharmacological therapies (e.g., physical therapy, heat/cold packs).
Alternative Medicines in Bangladesh
Similar medicines available in the market
Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.