Take orally with food or milk to minimize gastrointestinal upset. Swallow the capsule whole with water; do not crush, chew, or open.

Ibruxen exerts its therapeutic effects by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever.

• •Known hypersensitivity to Ibuprofen or other NSAIDs, or to any component of the formulation.
• •Active or history of recurrent peptic ulceration or gastrointestinal bleeding.
• •Severe heart failure, renal failure, or hepatic failure.
• •Third trimester of pregnancy.

Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.

Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, drowsiness, headache, tinnitus, and nystagmus. Severe overdose can lead to acute renal failure, hepatic damage, hypotension, respiratory depression, and coma. Management involves symptomatic and supportive treatment, including gastric lavage or activated charcoal if recent ingestion.

Avoid in the third trimester of pregnancy due to potential fetal harm and prolonged labor. Use with caution in the first and second trimesters only if the potential benefit outweighs the risk. Limited data on excretion into breast milk; use with caution during lactation and monitor the infant for adverse effects.