Ibruxen
Generic Name
Ibruxen 140 mg capsule
Manufacturer
Pharma Innovations Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ibruxen 140 mg capsule | ৳ 350.00 | N/A |
Description
Overview of the medicine
Ibruxen 140 mg Capsule is a non-steroidal anti-inflammatory drug (NSAID) used for the relief of mild to moderate pain, inflammation, and fever.
Uses & Indications
Dosage
Adults
1-2 capsules (140-280 mg) every 6-8 hours as needed, not exceeding 840 mg (6 capsules) in 24 hours.
Elderly
Lower doses may be required. Monitor renal and hepatic function regularly.
Renal_impairment
Dosage adjustment is necessary. Start with lower doses and monitor renal function closely. Avoid in severe renal impairment.
How to Take
Take orally with food or milk to minimize gastrointestinal upset. Swallow the capsule whole with water; do not crush, chew, or open.
Mechanism of Action
Ibruxen exerts its therapeutic effects by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins, which are mediators of pain, inflammation, and fever.
Pharmacokinetics
Onset
Analgesic effect typically begins within 30-60 minutes.
Excretion
Mainly excreted in the urine as metabolites and conjugates, with a small amount excreted unchanged.
Half life
Approximately 2-4 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 1-2 hours after oral administration.
Metabolism
Primarily metabolized in the liver via oxidation and glucuronidation.
Side Effects
Contraindications
- Known hypersensitivity to Ibuprofen or other NSAIDs, or to any component of the formulation.
- Active or history of recurrent peptic ulceration or gastrointestinal bleeding.
- Severe heart failure, renal failure, or hepatic failure.
- Third trimester of pregnancy.
Drug Interactions
Corticosteroids
Increased risk of gastrointestinal ulceration and bleeding.
Lithium and Methotrexate
May increase plasma concentrations and toxicity of these drugs.
Diuretics and ACE inhibitors
May reduce the antihypertensive effect and increase the risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, drowsiness, headache, tinnitus, and nystagmus. Severe overdose can lead to acute renal failure, hepatic damage, hypotension, respiratory depression, and coma. Management involves symptomatic and supportive treatment, including gastric lavage or activated charcoal if recent ingestion.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to potential fetal harm and prolonged labor. Use with caution in the first and second trimesters only if the potential benefit outweighs the risk. Limited data on excretion into breast milk; use with caution during lactation and monitor the infant for adverse effects.
Side Effects
Contraindications
- Known hypersensitivity to Ibuprofen or other NSAIDs, or to any component of the formulation.
- Active or history of recurrent peptic ulceration or gastrointestinal bleeding.
- Severe heart failure, renal failure, or hepatic failure.
- Third trimester of pregnancy.
Drug Interactions
Corticosteroids
Increased risk of gastrointestinal ulceration and bleeding.
Lithium and Methotrexate
May increase plasma concentrations and toxicity of these drugs.
Diuretics and ACE inhibitors
May reduce the antihypertensive effect and increase the risk of renal impairment.
Anticoagulants (e.g., Warfarin)
Increased risk of bleeding.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose may include nausea, vomiting, epigastric pain, lethargy, drowsiness, headache, tinnitus, and nystagmus. Severe overdose can lead to acute renal failure, hepatic damage, hypotension, respiratory depression, and coma. Management involves symptomatic and supportive treatment, including gastric lavage or activated charcoal if recent ingestion.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy due to potential fetal harm and prolonged labor. Use with caution in the first and second trimesters only if the potential benefit outweighs the risk. Limited data on excretion into breast milk; use with caution during lactation and monitor the infant for adverse effects.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved by relevant health authorities
Patent Status
Patent expired for generic formulation
Clinical Trials
General information about clinical trials for this specific formulation is limited. However, NSAIDs have been extensively studied for their efficacy and safety.
Lab Monitoring
- Complete Blood Count (CBC) for long-term use.
- Renal function tests (e.g., serum creatinine, BUN) periodically, especially in elderly or patients with pre-existing renal conditions.
- Liver function tests (e.g., ALT, AST) if long-term use or hepatic impairment is suspected.
Doctor Notes
- Assess patient's cardiovascular and gastrointestinal risk factors before prescribing.
- Use the lowest effective dose for the shortest possible duration.
- Educate patients on potential side effects and when to seek medical attention.
Patient Guidelines
- Take with food or milk to reduce stomach irritation.
- Do not exceed the recommended dose or duration of treatment.
- Report any unusual bleeding, persistent stomach pain, or dark stools to your doctor immediately.
- Avoid concurrent use with other NSAIDs unless directed by a physician.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Ibruxen may cause dizziness or visual disturbances in some individuals. Patients should be cautioned about driving or operating machinery if they experience these side effects.
Lifestyle Advice
- Avoid excessive alcohol consumption while taking this medicine.
- Stay hydrated by drinking plenty of fluids.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.