Ibsan
Generic Name
Irbesartan
Manufacturer
Popular Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ibsan 75 mg tablet | ৳ 5.00 | N/A |
Description
Overview of the medicine
Irbesartan is an Angiotensin II Receptor Blocker (ARB) used to treat high blood pressure and to protect the kidneys from damage due to diabetes.
Uses & Indications
Dosage
Adults
Hypertension: Initial dose is 75 mg once daily. The dose can be increased to 150 mg once daily, and if needed, to a maximum of 300 mg once daily. Diabetic Nephropathy: Initial dose is 75 mg once daily, usually escalated to 300 mg once daily.
Elderly
No initial dosage adjustment is usually necessary for elderly patients.
Renal_impairment
No initial dosage adjustment is necessary for patients with mild to moderate renal impairment. For severe impairment, caution is advised, and close monitoring of renal function and potassium levels is recommended.
How to Take
Ibsan 75 mg Tablet should be taken orally once daily, with or without food. It is recommended to take the tablet at approximately the same time each day.
Mechanism of Action
Irbesartan selectively blocks the binding of angiotensin II to the AT1 receptor in various tissues, including vascular smooth muscle and the adrenal gland. This prevents the vasoconstrictive and aldosterone-secreting effects of angiotensin II, leading to vasodilation and reduced blood pressure.
Pharmacokinetics
Onset
Antihypertensive effect begins within 1-2 hours, with maximum effect generally achieved within 4-6 hours.
Excretion
Approximately 20% of the administered dose is excreted in the urine (primarily unchanged), and the remainder (80%) is excreted in the feces via biliary excretion.
Half life
The elimination half-life is approximately 11-15 hours.
Absorption
Rapidly absorbed from the gastrointestinal tract. Absolute bioavailability is approximately 60-80%. Peak plasma concentrations are reached 1.5-2 hours after oral administration.
Metabolism
Minimally metabolized by the liver, primarily via oxidation by CYP2C9. Approximately 20% of the dose is metabolized.
Side Effects
Contraindications
- Hypersensitivity to irbesartan or any of the excipients.
- Pregnancy (especially during the second and third trimesters) due to risk of fetal toxicity.
- Concomitant use with aliskiren-containing products in patients with diabetes or renal impairment (GFR < 60 mL/min/1.73 m²).
Drug Interactions
Diuretics and other antihypertensive agents
May increase the hypotensive effect.
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
May reduce the antihypertensive effect and increase the risk of renal function deterioration, including possible acute renal failure.
Potassium-sparing diuretics, potassium supplements, or potassium-containing salt substitutes
May lead to hyperkalemia.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children. Do not use after the expiry date.
Overdose
Symptoms of overdose are likely to include hypotension (low blood pressure) and possibly tachycardia or bradycardia. Management involves symptomatic and supportive treatment. If recent ingestion, consider gastric lavage. Monitor vital signs and administer intravenous fluids as necessary.
Pregnancy & Lactation
Ibsan is contraindicated during pregnancy, especially in the second and third trimesters, due to the risk of fetal toxicity. It is not recommended during breastfeeding as it is unknown if irbesartan is excreted in human milk.
Side Effects
Contraindications
- Hypersensitivity to irbesartan or any of the excipients.
- Pregnancy (especially during the second and third trimesters) due to risk of fetal toxicity.
- Concomitant use with aliskiren-containing products in patients with diabetes or renal impairment (GFR < 60 mL/min/1.73 m²).
Drug Interactions
Diuretics and other antihypertensive agents
May increase the hypotensive effect.
Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
May reduce the antihypertensive effect and increase the risk of renal function deterioration, including possible acute renal failure.
Potassium-sparing diuretics, potassium supplements, or potassium-containing salt substitutes
May lead to hyperkalemia.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children. Do not use after the expiry date.
Overdose
Symptoms of overdose are likely to include hypotension (low blood pressure) and possibly tachycardia or bradycardia. Management involves symptomatic and supportive treatment. If recent ingestion, consider gastric lavage. Monitor vital signs and administer intravenous fluids as necessary.
Pregnancy & Lactation
Ibsan is contraindicated during pregnancy, especially in the second and third trimesters, due to the risk of fetal toxicity. It is not recommended during breastfeeding as it is unknown if irbesartan is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 36 months from the date of manufacture. Refer to the specific product packaging for exact details.
Availability
Pharmacies, Hospitals
Approval Status
Approved by major regulatory bodies globally
Patent Status
Generic available
Clinical Trials
Irbesartan has been extensively studied in clinical trials demonstrating its efficacy in reducing blood pressure and improving renal outcomes in diabetic nephropathy. Ongoing research may explore its role in other cardiovascular conditions.
Lab Monitoring
- Serum creatinine and potassium levels should be monitored periodically, especially in patients with renal impairment or those concomitantly receiving potassium-sparing diuretics or potassium supplements.
- Blood pressure should be regularly monitored to assess treatment effectiveness.
Doctor Notes
- Regularly monitor renal function and serum potassium, particularly in patients initiating therapy, those with pre-existing renal impairment, or when co-administering NSAIDs or potassium-sparing diuretics.
- Counsel patients on the importance of adherence to therapy and symptoms of angioedema (e.g., swelling of the face, lips, tongue) requiring immediate medical attention.
- Advise against use during pregnancy; ensure female patients of childbearing potential are aware of the risks and use effective contraception.
Patient Guidelines
- Take Ibsan exactly as prescribed by your doctor and do not stop taking it without consulting them, even if you feel well.
- Inform your doctor immediately if you experience any symptoms of an allergic reaction (e.g., swelling of the face, lips, tongue, or throat) or severe dizziness.
- Regularly monitor your blood pressure at home as advised by your healthcare provider.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Ibsan may cause dizziness or lightheadedness, especially after the first dose or when the dose is increased. Patients should be cautious when driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain a healthy lifestyle, including a balanced diet low in sodium, regular exercise, and maintaining a healthy weight.
- Avoid excessive alcohol consumption as it can contribute to high blood pressure and interfere with medication effects.
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