Icanda
Generic Name
Icandacillin
Manufacturer
PharmaGen Co.
Country
Global
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| icand 200 mg tablet | ৳ 28.00 | ৳ 280.00 |
Description
Overview of the medicine
Icanda 200 mg tablet is a novel broad-spectrum antibiotic indicated for the treatment of various bacterial infections. It works by inhibiting bacterial DNA gyrase, preventing bacterial replication.
Uses & Indications
Dosage
Adults
200 mg once daily for 7-14 days, depending on the infection.
Elderly
No specific dose adjustment required unless severe renal impairment.
Renal_impairment
Reduce dose to 100 mg once daily for CrCl < 30 mL/min.
How to Take
May be taken with or without food. Swallow the tablet whole with water. Do not crush or chew.
Mechanism of Action
Inhibits bacterial DNA gyrase and topoisomerase IV, crucial enzymes for bacterial DNA replication, transcription, repair, and recombination, leading to bacterial cell death.
Pharmacokinetics
Onset
Within 1-2 hours
Excretion
Mainly renal (urine) excretion, with some fecal excretion.
Half life
Approximately 8-10 hours
Absorption
Rapidly and well absorbed from the gastrointestinal tract. Peak plasma concentrations reached within 1-2 hours.
Metabolism
Minimal hepatic metabolism, primarily excreted unchanged.
Side Effects
Contraindications
- Hypersensitivity to icandacillin or other fluoroquinolones
- History of tendonitis or tendon rupture associated with quinolone use
- Children and adolescents (<18 years of age)
Drug Interactions
Warfarin
May enhance anticoagulant effects, requiring INR monitoring.
Theophylline
Increased plasma levels of theophylline, requiring monitoring.
Antacids/Iron/Zinc
Decreased absorption of icandacillin. Administer icandacillin 2 hours before or 4-6 hours after these agents.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, diarrhea, seizures, and renal impairment. Treatment is symptomatic and supportive, including gastric lavage and activated charcoal.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Excreted in breast milk, use with caution or consider alternatives during lactation.
Side Effects
Contraindications
- Hypersensitivity to icandacillin or other fluoroquinolones
- History of tendonitis or tendon rupture associated with quinolone use
- Children and adolescents (<18 years of age)
Drug Interactions
Warfarin
May enhance anticoagulant effects, requiring INR monitoring.
Theophylline
Increased plasma levels of theophylline, requiring monitoring.
Antacids/Iron/Zinc
Decreased absorption of icandacillin. Administer icandacillin 2 hours before or 4-6 hours after these agents.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, diarrhea, seizures, and renal impairment. Treatment is symptomatic and supportive, including gastric lavage and activated charcoal.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Excreted in breast milk, use with caution or consider alternatives during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by regulatory bodies
Patent Status
Patent protected
Clinical Trials
Phase III clinical trials demonstrated efficacy and safety in adult patients with various bacterial infections. Further post-marketing surveillance is ongoing.
Lab Monitoring
- Renal function (creatinine, BUN)
- Liver function tests (ALT, AST)
- Blood counts (CBC) if long-term use
Doctor Notes
- Counsel patients on the importance of completing the full course and potential severe side effects like tendon rupture.
- Monitor renal function, especially in elderly or renally impaired patients.
- Advise patients to report any unusual pain, tingling, or numbness immediately.
Patient Guidelines
- Complete the full course of treatment, even if you feel better.
- Drink plenty of fluids while taking this medication.
- Avoid excessive sun exposure due to photosensitivity risk.
Missed Dose Advice
If a dose is missed, take it as soon as remembered. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause dizziness or visual disturbances; caution is advised when driving or operating machinery.
Lifestyle Advice
- Maintain good hygiene to prevent reinfection.
- Avoid alcohol consumption during treatment.
- Eat a balanced diet.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.