Icosa
Generic Name
Icosapent Ethyl
Manufacturer
Example Manufacturer Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| icosa 1 gm capsule | ৳ 50.00 | ৳ 500.00 |
Description
Overview of the medicine
Icosa-1 gm Capsule contains Icosapent Ethyl, a highly purified omega-3 fatty acid (eicosapentaenoic acid ethyl ester). It is primarily used as an adjunct to diet to reduce very high triglyceride levels and as an adjunct to statin therapy to reduce the risk of cardiovascular events in certain patients.
Uses & Indications
Dosage
Adults
2 gm orally twice daily with food (total 4 gm/day).
Elderly
No specific dose adjustment is required based on age alone, but caution should be exercised due to potential for decreased renal function.
Renal_impairment
No specific dose adjustment required for mild to moderate renal impairment. Data limited for severe renal impairment.
How to Take
Take orally with food. Swallow capsules whole; do not break, crush, dissolve, or chew.
Mechanism of Action
Icosapent ethyl reduces hepatic very low-density lipoprotein triglyceride (VLDL-TG) synthesis and secretion, and enhances triglyceride clearance from VLDL particles. It may also inhibit diacylglycerol acyltransferase, increase beta-oxidation, and reduce circulating fatty acids that are precursors to triglycerides. Additionally, it has anti-inflammatory and anti-platelet effects.
Pharmacokinetics
Onset
Triglyceride-lowering effects typically observed within weeks; cardiovascular benefits take longer (months to years).
Excretion
Excreted primarily as carbon dioxide and water via respiration and urine, with minimal fecal excretion.
Half life
Approximately 89 hours for total EPA after single dose, with steady state reached in about 2 weeks.
Absorption
Readily absorbed after oral administration, peak plasma concentrations typically achieved within 5-9 hours. Absorption is enhanced with a high-fat meal.
Metabolism
Primarily metabolized in the liver by hepatic lipases to eicosapentaenoic acid (EPA) and then through beta-oxidation, similar to dietary fatty acids.
Side Effects
Contraindications
- Known hypersensitivity to icosapent ethyl or any components of the product.
- Known hypersensitivity to fish and shellfish.
Drug Interactions
Anticoagulants/Antiplatelet Agents
Increased risk of bleeding. Monitor patients receiving concurrent therapy with anticoagulants or antiplatelet agents.
Storage
Store at room temperature (20°C to 25°C), away from moisture and light. Do not freeze.
Overdose
Overdose experience is limited. Treatment should be symptomatic and supportive. It is not dialyzable.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Caution advised during lactation; it is unknown if icosapent ethyl is excreted in human milk.
Side Effects
Contraindications
- Known hypersensitivity to icosapent ethyl or any components of the product.
- Known hypersensitivity to fish and shellfish.
Drug Interactions
Anticoagulants/Antiplatelet Agents
Increased risk of bleeding. Monitor patients receiving concurrent therapy with anticoagulants or antiplatelet agents.
Storage
Store at room temperature (20°C to 25°C), away from moisture and light. Do not freeze.
Overdose
Overdose experience is limited. Treatment should be symptomatic and supportive. It is not dialyzable.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Caution advised during lactation; it is unknown if icosapent ethyl is excreted in human milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date
Availability
Available in pharmacies nationwide
Approval Status
Approved by FDA (for generic Icosapent Ethyl products)
Patent Status
Patent expired for generic versions available; original patent held by Amarin Pharma Inc.
Clinical Trials
The REDUCE-IT trial, a large placebo-controlled study, demonstrated a significant reduction in cardiovascular events in high-risk patients with elevated triglycerides who were already on statin therapy.
Lab Monitoring
- Baseline and periodic monitoring of triglyceride levels.
- Liver function tests (ALT/AST) periodically, especially in patients with hepatic impairment.
- INR/PT monitoring in patients on anticoagulants.
Doctor Notes
- Emphasize adherence to diet and exercise alongside medication.
- Monitor for signs of bleeding, particularly in patients on concomitant anticoagulant or antiplatelet therapy.
- Regularly assess triglyceride levels, and liver function tests (ALT/AST) periodically.
Patient Guidelines
- Take with food.
- Do not break, crush, dissolve, or chew capsules.
- Follow a lipid-lowering diet and exercise program.
- Inform your doctor about all medications you are taking, especially anticoagulants.
- Report any signs of bleeding or atrial fibrillation.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at once.
Driving Precautions
Icosa-1 gm Capsule is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Maintain a healthy diet low in saturated and trans fats.
- Regular physical activity is recommended.
- Avoid excessive alcohol consumption.
- Quit smoking.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.