Iluca
Generic Name
Pregabalin
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| iluca 150 mg capsule | ৳ 23.00 | ৳ 92.00 |
Description
Overview of the medicine
Iluca-150 mg Capsule contains Pregabalin, an anticonvulsant and neuropathic pain agent. It is used to treat neuropathic pain, fibromyalgia, and as an add-on therapy for partial-onset seizures.
Uses & Indications
Dosage
Adults
For neuropathic pain, initial dose 75 mg twice daily or 50 mg three times daily, adjusted based on response and tolerability, up to a maximum of 600 mg/day. A 150 mg capsule is often taken once or twice daily. For fibromyalgia, start 75 mg BID, can increase to 150 mg BID.
Elderly
Dose adjustment may be necessary in elderly patients due to age-related decrease in renal function. Starting with a lower dose and careful titration is advised.
Renal_impairment
Significant dose reduction is required based on creatinine clearance. For CrCl 30-60 mL/min, max 300 mg/day; for CrCl 15-30 mL/min, max 150 mg/day; for CrCl <15 mL/min, max 75 mg/day or 25-50 mg daily/every other day.
How to Take
Take orally with or without food. Swallow the capsule whole with water. Do not chew, crush, or open the capsule.
Mechanism of Action
Pregabalin binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system, thereby modulating the release of various neurotransmitters including glutamate, norepinephrine, and substance P. This action reduces neuronal excitability.
Pharmacokinetics
Onset
Analgesic effects typically begin within 1 week for neuropathic pain. Anxiolytic effects may appear sooner.
Excretion
Primarily excreted unchanged in the urine (approximately 98% of the dose).
Half life
Approximately 6.3 hours, independent of dose.
Absorption
Rapidly absorbed following oral administration with high bioavailability (≥90%). Peak plasma concentrations are reached within approximately 1.5 hours.
Metabolism
Pregabalin undergoes negligible metabolism in humans; less than 0.1% of the dose is excreted as metabolites.
Side Effects
Contraindications
- Hypersensitivity to Pregabalin or any of the excipients in the formulation.
- Severe respiratory depression (due to potential for exacerbation).
Drug Interactions
ACE inhibitors
May increase the risk of angioedema when co-administered with Pregabalin.
CNS depressants (opioids, benzodiazepines, ethanol)
Concomitant use may potentiate CNS depressant effects, leading to increased somnolence and respiratory depression.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and, rarely, coma. Treatment is supportive and symptomatic. Hemodialysis may be useful in patients with compromised renal function.
Pregnancy & Lactation
Pregnancy Category C: Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Pregabalin is excreted into human breast milk; a decision should be made whether to discontinue nursing or to discontinue the drug.
Side Effects
Contraindications
- Hypersensitivity to Pregabalin or any of the excipients in the formulation.
- Severe respiratory depression (due to potential for exacerbation).
Drug Interactions
ACE inhibitors
May increase the risk of angioedema when co-administered with Pregabalin.
CNS depressants (opioids, benzodiazepines, ethanol)
Concomitant use may potentiate CNS depressant effects, leading to increased somnolence and respiratory depression.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, confusion, agitation, and, rarely, coma. Treatment is supportive and symptomatic. Hemodialysis may be useful in patients with compromised renal function.
Pregnancy & Lactation
Pregnancy Category C: Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Pregabalin is excreted into human breast milk; a decision should be made whether to discontinue nursing or to discontinue the drug.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture.
Availability
Available in pharmacies
Approval Status
Approved by regulatory authorities
Patent Status
Off-patent for generic versions
Clinical Trials
Pregabalin has undergone extensive clinical trials demonstrating its efficacy and safety for approved indications, including studies on neuropathic pain, fibromyalgia, and partial-onset seizures.
Lab Monitoring
- Routine lab monitoring is generally not required. However, renal function should be monitored in elderly patients or those with pre-existing renal impairment, and dose adjusted accordingly.
Doctor Notes
- Counsel patients on the risk of CNS depression when co-administered with other CNS depressants.
- Gradual tapering is crucial upon discontinuation to minimize withdrawal symptoms.
- Monitor renal function, especially in elderly and patients with pre-existing renal impairment, and adjust dose accordingly.
- Assess for potential for abuse and dependence, particularly in patients with a history of substance abuse.
Patient Guidelines
- Do not stop taking Iluca-150 mg Capsule suddenly without consulting your doctor, as this may lead to withdrawal symptoms.
- Be cautious when driving or operating machinery, as this medicine may cause dizziness and somnolence.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to catch up.
Driving Precautions
Iluca-150 mg Capsule may cause dizziness, somnolence, and blurred vision, which can impair your ability to drive or operate machinery. Patients should be advised not to drive or operate complex machinery until they are reasonably certain that Iluca-150 mg Capsule does not affect their ability to perform such activities.
Lifestyle Advice
- Avoid alcohol consumption while taking Pregabalin, as it may enhance CNS depressant effects.
- Maintain a balanced diet and regular exercise to manage potential weight gain.
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