Imatin
Generic Name
Imatinib
Manufacturer
XYZ Pharmaceuticals
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| imatin 400 mg tablet | ৳ 400.00 | ৳ 4,000.00 |
Description
Overview of the medicine
Imatinib is a targeted therapy used to treat certain types of cancer, primarily chronic myeloid leukemia (CML) and gastrointestinal stromal tumors (GIST). It works by blocking specific proteins that promote cancer cell growth.
Uses & Indications
Dosage
Adults
For CML (chronic phase): 400 mg once daily. For GIST: 400 mg once daily. Dosage may be adjusted based on response and tolerability, up to 800 mg daily in divided doses for some indications.
Elderly
No specific dose adjustment generally required, but monitor for adverse effects.
Renal_impairment
Patients with severe renal impairment should start at a reduced dose (e.g., 300 mg daily for CML chronic phase) and be monitored closely.
How to Take
Take orally with a meal and a large glass of water to minimize gastrointestinal irritation. Do not crush or cut tablets.
Mechanism of Action
Imatinib selectively inhibits the Bcr-Abl tyrosine kinase, which is characteristic of chronic myeloid leukemia and acute lymphoblastic leukemia. It also inhibits the receptor tyrosine kinases for platelet-derived growth factor (PDGF) and stem cell factor (SCF), c-KIT. These inhibitions lead to the suppression of proliferation and induction of apoptosis in various cancer cell lines.
Pharmacokinetics
Onset
Clinical response can be observed within weeks to months.
Excretion
Primarily in feces (68%), with a smaller amount in urine (13%) as metabolites and unchanged drug.
Half life
Approximately 18 hours for imatinib and 40 hours for its active metabolite.
Absorption
Well absorbed orally, peak plasma concentration reached in 2-4 hours. Bioavailability is about 98%.
Metabolism
Primarily hepatic via CYP3A4 to its main active metabolite, N-desmethyl imatinib.
Side Effects
Contraindications
- Hypersensitivity to imatinib or any component of the formulation.
Drug Interactions
Warfarin
Imatinib may increase anticoagulant effect.
Other chemotherapy agents
Increased myelosuppression when combined with certain chemotherapies.
Strong CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, clarithromycin)
May increase imatinib plasma concentrations, increasing toxicity risk.
Strong CYP3A4 inducers (e.g., rifampicin, phenytoin, carbamazepine, St. John's wort)
May decrease imatinib plasma concentrations, reducing efficacy.
Storage
Store below 30°C (86°F) in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Limited experience. Overdose may lead to increased severity of side effects such as myelosuppression, gastrointestinal symptoms, and liver damage. Treatment is supportive.
Pregnancy & Lactation
Pregnancy Category D. May cause fetal harm. Should not be used during pregnancy unless the potential benefit outweighs the potential risk to the fetus. Women of childbearing potential should use effective contraception.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 2-3 years from manufacturing date.
Availability
Pharmacies, hospitals
Approval Status
FDA approved
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have established imatinib's efficacy and safety in CML, GIST, and other indications, leading to its global approval and widespread use. Key trials include IRIS for CML.
Lab Monitoring
- Complete blood counts (CBC) with differential weekly for the first month, then monthly.
- Liver function tests (LFTs) weekly for the first month, then monthly or as clinically indicated.
- Renal function tests, electrolytes.
Doctor Notes
- Counsel patients on potential severe adverse effects, including fluid retention, myelosuppression, and hepatotoxicity.
- Emphasize adherence to dosage and monitoring schedule.
- Educate on drug-drug and drug-food interactions.
Patient Guidelines
- Take imatinib with a meal and a full glass of water.
- Do not crush or cut the tablet.
- Report any unusual bleeding, bruising, swelling, or yellowing of the skin/eyes immediately.
- Attend all scheduled blood tests and doctor appointments.
- Use effective contraception during treatment and for a period after if you are a woman of childbearing potential.
Missed Dose Advice
If a dose is missed, take it as soon as you remember, unless it is almost time for your next dose. Do not take a double dose to make up for a missed one.
Driving Precautions
May cause dizziness, blurred vision, or fatigue. Patients should be cautious when driving or operating machinery until they know how imatinib affects them.
Lifestyle Advice
- Maintain good hydration. Avoid grapefruit and St. John's wort. Discuss all other medications, supplements, and herbal remedies with your doctor.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.