Orally, swallowed whole with water, with or without food.

Loperamide binds to opiate receptors in the gut wall, reducing intestinal motility and fluid/electrolyte secretion. Simethicone is an antiflatulent that reduces the surface tension of gas bubbles in the gastrointestinal tract, causing them to coalesce and be more easily expelled.

• •Hypersensitivity to Loperamide, Simethicone, or any component.
• •Patients with bloody stools or high fever.
• •Patients with bacterial enterocolitis (e.g., Salmonella, Shigella, E. coli O157:H7).
• •Patients with pseudomembranous colitis associated with broad-spectrum antibiotic use.
• •Children under 6 years of age.

Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.

Symptoms of Loperamide overdose include central nervous system depression (stupor, coordination impairment, somnolence, miosis, muscle hypertonia, respiratory depression), urinary retention, and ileus. Cardiac events (QT prolongation, Torsades de Pointes) can also occur. Simethicone overdose is unlikely to cause adverse effects due to lack of systemic absorption. Treatment for Loperamide overdose is symptomatic and supportive; naloxone may be used to reverse opioid effects, with monitoring for recurrence.

Use during pregnancy only if clearly needed and the potential benefits outweigh the potential risks to the fetus. Small amounts of loperamide may appear in breast milk; caution should be exercised when administered to a nursing mother. Consult a doctor.