Inflacin
Generic Name
Indomethacin
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| inflacin 25 mg capsule | ৳ 0.60 | N/A |
Description
Overview of the medicine
Inflacin is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, swelling, and stiffness caused by arthritis, gout, bursitis, and tendinitis. It works by blocking the body's production of certain natural substances that cause inflammation.
Uses & Indications
Dosage
Adults
25 mg two to three times daily, increased if necessary up to a maximum of 150-200 mg daily in divided doses.
Elderly
Lower initial doses recommended, closely monitor for adverse effects.
Renal_impairment
Caution advised, dose adjustment may be necessary in severe impairment.
How to Take
Orally with food or milk to minimize gastrointestinal upset.
Mechanism of Action
Inhibits cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing prostaglandin synthesis which mediates inflammation, pain, and fever.
Pharmacokinetics
Onset
Onset of pain relief usually within 30 minutes, peak effect 2-4 hours.
Excretion
Excreted primarily in urine (60%) and feces (33%).
Half life
Approximately 4.5 hours.
Absorption
Rapidly and completely absorbed from the gastrointestinal tract.
Metabolism
Extensively metabolized in the liver, primarily by demethylation, debenzoylation, and glucuronidation.
Side Effects
Contraindications
- Hypersensitivity to NSAIDs
- Active gastrointestinal bleeding or ulcer
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after aspirin or other NSAIDs
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Digoxin
Increased digoxin levels.
Lithium
Increased lithium levels.
Warfarin
Increased risk of bleeding.
Methotrexate
Increased methotrexate toxicity.
Diuretics/ACE inhibitors
Reduced efficacy and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture.
Overdose
Symptoms may include nausea, vomiting, stomach pain, dizziness, and drowsiness. Treatment is supportive, potentially gastric lavage and activated charcoal.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy. Use with caution in first and second trimesters if benefits outweigh risks. Not recommended during breastfeeding.
Side Effects
Contraindications
- Hypersensitivity to NSAIDs
- Active gastrointestinal bleeding or ulcer
- Severe renal or hepatic impairment
- Severe heart failure
- Third trimester of pregnancy
- History of asthma, urticaria, or allergic-type reactions after aspirin or other NSAIDs
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Digoxin
Increased digoxin levels.
Lithium
Increased lithium levels.
Warfarin
Increased risk of bleeding.
Methotrexate
Increased methotrexate toxicity.
Diuretics/ACE inhibitors
Reduced efficacy and increased risk of renal impairment.
Storage
Store below 30°C in a dry place, away from light and moisture.
Overdose
Symptoms may include nausea, vomiting, stomach pain, dizziness, and drowsiness. Treatment is supportive, potentially gastric lavage and activated charcoal.
Pregnancy & Lactation
Avoid in the third trimester of pregnancy. Use with caution in first and second trimesters if benefits outweigh risks. Not recommended during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months
Availability
Pharmacies, hospitals
Approval Status
Approved by DGDA
Patent Status
Generic available, original patent expired
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials support its efficacy and safety for approved indications.
Lab Monitoring
- Monitor complete blood count, liver function tests, and renal function tests periodically, especially during long-term therapy.
Doctor Notes
- Consider lowest effective dose for shortest duration.
- Monitor GI and cardiovascular risk factors.
- Adjust dose for renal impairment.
Patient Guidelines
- Take with food to reduce stomach upset.
- Do not exceed recommended dose.
- Report any unusual bleeding or bruising.
Missed Dose Advice
Take the missed dose as soon as you remember, unless it is almost time for your next dose. Do not double the dose.
Driving Precautions
May cause dizziness or drowsiness; exercise caution when driving or operating machinery.
Lifestyle Advice
- Avoid alcohol.
- Stay hydrated.
- Limit sun exposure as some NSAIDs can cause photosensitivity.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.
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