Inflect
Generic Name
Fluctinacin 500 mg Tablet
Manufacturer
MediHealth Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| inflect 500 mg tablet | ৳ 10.03 | N/A |
Description
Overview of the medicine
Inflect 500 mg Tablet is a broad-spectrum antibiotic used to treat various bacterial infections, including respiratory tract infections, urinary tract infections, skin and soft tissue infections, and certain sexually transmitted diseases.
Uses & Indications
Dosage
Adults
500 mg once daily for 7-14 days, depending on the infection. For severe infections, 500 mg twice daily may be prescribed.
Elderly
No specific dose adjustment typically required unless severe renal impairment is present.
Renal_impairment
Dosage adjustment is necessary for patients with creatinine clearance < 50 mL/min. For CrCl 20-49 mL/min, 250 mg every 24 hours; for CrCl < 20 mL/min, 250 mg every 48 hours.
How to Take
Take orally with a glass of water, with or without food. Do not crush or chew the tablet. Maintain adequate hydration.
Mechanism of Action
Inflect inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for bacterial DNA replication, transcription, repair, and recombination. This leads to the inhibition of bacterial cell growth and death.
Pharmacokinetics
Onset
Varies by infection type, generally within hours for antibacterial effect.
Excretion
Mainly excreted unchanged in the urine via glomerular filtration and tubular secretion.
Half life
Approximately 6-8 hours, allowing for once or twice daily dosing.
Absorption
Rapidly and well absorbed from the gastrointestinal tract, with peak plasma concentrations occurring within 1-2 hours.
Metabolism
Minimally metabolized in the liver; primarily excreted unchanged.
Side Effects
Contraindications
- •Hypersensitivity to fluctinacin or other fluoroquinolones
- •History of tendinitis or tendon rupture associated with fluoroquinolone use
- •Children under 18 years of age (due to cartilage damage risk)
- •Epilepsy or other seizure disorders
Drug Interactions
NSAIDs
May increase the risk of CNS stimulation and seizures when co-administered with fluoroquinolones.
Warfarin
May enhance the anticoagulant effect, increasing bleeding risk. Monitor INR closely.
Corticosteroids
Increased risk of tendon rupture when co-administered with fluoroquinolones.
Antacids (containing magnesium/aluminum), sucralfate, iron supplements, multivitamins (containing zinc)
Reduce absorption of Inflect. Take Inflect 2 hours before or 6 hours after these agents.
Storage
Store below 30°C in a dry place, away from light. Keep out of reach of children.
Overdose
In case of overdose, seek immediate medical attention. Symptoms may include nausea, vomiting, dizziness, confusion, seizures, and prolonged QT interval. Treatment is symptomatic and supportive; hemodialysis is generally not effective.
Pregnancy & Lactation
Not recommended during pregnancy due to potential risks to fetal cartilage development. Small amounts may pass into breast milk; use with caution or consider alternatives during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, Hospitals
Approval Status
Approved by DGDA
Patent Status
Patent Expired, Generic Available
WHO Essential Medicine
YesAlternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine
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