Inket
Generic Name
Inketin
Manufacturer
MediCorp Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| inket 10 mg tablet | ৳ 10.00 | N/A |
Description
Overview of the medicine
Inket 10 mg Tablet is a medication used to lower high cholesterol levels and reduce the risk of heart disease. It works by reducing the production of cholesterol in the liver.
Uses & Indications
Dosage
Adults
Initial dose 10 mg once daily, adjusted based on response up to 80 mg daily.
Elderly
No specific dose adjustment required based solely on age.
Renal_impairment
No dose adjustment required for mild to moderate renal impairment; use with caution in severe impairment.
How to Take
Take orally once daily, with or without food, at any time of day, but preferably at the same time each day.
Mechanism of Action
Inketin selectively inhibits HMG-CoA reductase, an enzyme that catalyzes the rate-limiting step in cholesterol biosynthesis. This inhibition reduces cholesterol levels in liver cells, leading to increased uptake of LDL from the bloodstream.
Pharmacokinetics
Onset
Lipid-lowering effects typically begin within 2 weeks.
Excretion
Mainly excreted via bile, with less than 2% eliminated in urine.
Half life
Approximately 14 hours.
Absorption
Rapidly absorbed, peak plasma concentrations reached within 1-2 hours.
Metabolism
Primarily metabolized by CYP3A4 in the liver.
Side Effects
Contraindications
- Active liver disease
- Unexplained persistent elevations of serum transaminases
- Pregnancy and lactation
Drug Interactions
Gemfibrozil
Increased risk of myopathy/rhabdomyolysis.
Cyclosporine
Increased risk of myopathy/rhabdomyolysis.
Strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole)
Increased Inketin plasma concentrations.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Treatment should be symptomatic and supportive. Monitor liver function and CK levels.
Pregnancy & Lactation
Contraindicated during pregnancy and lactation due to potential harm to the fetus/infant. Women of childbearing potential should use effective contraception.
Side Effects
Contraindications
- Active liver disease
- Unexplained persistent elevations of serum transaminases
- Pregnancy and lactation
Drug Interactions
Gemfibrozil
Increased risk of myopathy/rhabdomyolysis.
Cyclosporine
Increased risk of myopathy/rhabdomyolysis.
Strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole)
Increased Inketin plasma concentrations.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
No specific antidote. Treatment should be symptomatic and supportive. Monitor liver function and CK levels.
Pregnancy & Lactation
Contraindicated during pregnancy and lactation due to potential harm to the fetus/infant. Women of childbearing potential should use effective contraception.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies, hospitals
Approval Status
Approved by regulatory authorities
Patent Status
Patent expired for generic formulation
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of Inketin in reducing LDL-C and cardiovascular event risk.
Lab Monitoring
- Liver function tests (ALT, AST) before initiation and periodically thereafter.
- Creatine Kinase (CK) levels if muscle pain occurs.
Doctor Notes
- Counsel patients on lifestyle modifications alongside therapy.
- Emphasize adherence to treatment regimen.
- Monitor for signs of myopathy or liver injury.
Patient Guidelines
- Take as directed by your doctor.
- Inform your doctor about all other medications you are taking.
- Report any unexplained muscle pain, tenderness, or weakness immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Inketin is generally not expected to impair the ability to drive or operate machinery. However, if dizziness or other side effects occur, avoid driving.
Lifestyle Advice
- Maintain a healthy diet low in saturated and trans fats.
- Regular exercise is recommended.
- Avoid excessive alcohol consumption.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.