Iracet
Generic Name
Levetiracetam
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| iracet 250 mg tablet | ৳ 16.00 | ৳ 160.00 |
Description
Overview of the medicine
Iracet 250 mg Tablet contains Levetiracetam, an antiepileptic drug used to treat various types of seizures in adults and children.
Uses & Indications
Dosage
Adults
Initial dose: 500 mg twice daily. May be increased by 500 mg twice daily every 2 weeks to a maximum of 1500 mg twice daily (3000 mg/day).
Elderly
Dose adjustment may be necessary in elderly patients with impaired renal function. Start with lower doses.
Renal_impairment
Dose adjustment is required based on creatinine clearance. For CrCl 50-79 mL/min, 500-1000 mg BID; CrCl 30-49 mL/min, 250-750 mg BID; CrCl <30 mL/min, 250-500 mg BID. Dialysis patients: 500-1000 mg once daily, with an additional 250-500 mg post-dialysis.
How to Take
Administer orally, with or without food. Swallow tablets whole with liquid; do not chew, crush, or break. Take at the same time each day.
Mechanism of Action
The precise mechanism of action is unknown, but it is thought to involve binding to synaptic vesicle protein 2A (SV2A), which modulates neurotransmitter release.
Pharmacokinetics
Onset
Within days to weeks, depending on individual response and dose titration.
Excretion
Mainly renally excreted, with approximately 66% of the dose excreted unchanged in urine and 24% as the inactive carboxylic acid metabolite.
Half life
Approximately 7 hours in adults, shorter in children (5-6 hours).
Absorption
Rapidly and almost completely absorbed after oral administration, with peak plasma concentrations occurring within 1 hour. Bioavailability is approximately 100%.
Metabolism
Minimally metabolized; primarily by hydrolysis of the acetamide group (approximately 24% of the dose). Not extensively metabolized by hepatic cytochrome P450 enzymes.
Side Effects
Contraindications
- Known hypersensitivity to Levetiracetam or any components of the formulation.
Drug Interactions
Alcohol
May increase CNS depression and impair psychomotor performance.
Methotrexate
Decreased renal clearance of methotrexate leading to increased plasma concentrations and potential toxicity. Monitor methotrexate levels.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, agitation, aggression, depressed level of consciousness, respiratory depression, and coma. Management is primarily supportive; activated charcoal may be considered shortly after ingestion. Hemodialysis can remove Levetiracetam.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted into human milk; caution advised during breastfeeding.
Side Effects
Contraindications
- Known hypersensitivity to Levetiracetam or any components of the formulation.
Drug Interactions
Alcohol
May increase CNS depression and impair psychomotor performance.
Methotrexate
Decreased renal clearance of methotrexate leading to increased plasma concentrations and potential toxicity. Monitor methotrexate levels.
Storage
Store below 30°C in a dry place, away from direct light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose include somnolence, agitation, aggression, depressed level of consciousness, respiratory depression, and coma. Management is primarily supportive; activated charcoal may be considered shortly after ingestion. Hemodialysis can remove Levetiracetam.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. Excreted into human milk; caution advised during breastfeeding.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months from manufacturing date.
Availability
Available in pharmacies and hospitals
Approval Status
Approved
Patent Status
Off-patent (Generic available)
WHO Essential Medicine
YesClinical Trials
Extensively studied in numerous multinational, randomized, placebo-controlled clinical trials establishing its efficacy and safety for various seizure types.
Lab Monitoring
- Renal function tests (creatinine clearance) in patients with kidney impairment.
- Complete Blood Count (CBC) periodically, especially if persistent fatigue or infection occurs.
Doctor Notes
- Counsel patients on potential psychiatric and behavioral side effects, including suicidal ideation.
- Dose adjustment is crucial in renal impairment.
- Advise patients not to stop abruptly, and to report any new or worsening symptoms.
Patient Guidelines
- Do not stop taking this medicine suddenly without consulting your doctor, as it may worsen your seizures.
- Take the medicine exactly as prescribed by your doctor.
- Report any new or worsening mood changes, depression, or suicidal thoughts immediately to your doctor.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
This medicine may cause drowsiness, dizziness, or problems with coordination, especially at the beginning of treatment. Avoid driving or operating heavy machinery until you know how this medication affects you.
Lifestyle Advice
- Avoid alcohol consumption while on this medication, as it may increase side effects.
- Be cautious when performing tasks requiring mental alertness, such as driving or operating machinery, especially when starting treatment or increasing the dose.
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Global Brand Names
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