Iragon
Generic Name
Iragon (hypothetical ARB)
Manufacturer
MediCorp Pharma (Hypothetical)
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| iragon 25 mg tablet | ৳ 30.00 | ৳ 420.00 |
Description
Overview of the medicine
Iragon 25 mg Tablet is an angiotensin II receptor blocker (ARB) used to treat high blood pressure (hypertension) and heart failure. It helps to relax blood vessels, allowing blood to flow more easily.
Uses & Indications
Dosage
Adults
Initial dose 25 mg once daily. May be increased to 50 mg if necessary, based on patient response.
Elderly
No dosage adjustment generally required, but close monitoring is recommended.
Renal_impairment
For moderate impairment (CrCl 30-60 mL/min), initial dose 25 mg once daily. For severe impairment (CrCl <30 mL/min), not recommended or use with extreme caution.
How to Take
Take orally, once daily, with or without food. Swallow the tablet whole with a glass of water. Do not crush or chew.
Mechanism of Action
Iragon selectively blocks the binding of angiotensin II to the AT1 receptor, found in many tissues, including vascular smooth muscle and the adrenal gland. This inhibits the vasoconstrictor and aldosterone-secreting effects of angiotensin II, leading to vasodilation and reduced blood pressure.
Pharmacokinetics
Onset
Within 2 hours
Excretion
Mainly through feces via biliary excretion, with a small portion excreted in urine.
Half life
Approximately 12-15 hours
Absorption
Rapidly absorbed from the gastrointestinal tract, with peak plasma concentrations achieved within 1-2 hours.
Metabolism
Minimally metabolized in the liver; primarily excreted unchanged.
Side Effects
Contraindications
- •Hypersensitivity to iragon or any component of the formulation
- •Pregnancy (especially second and third trimesters)
- •Concomitant use with aliskiren in patients with diabetes or renal impairment
- •Severe hepatic impairment
Drug Interactions
Lithium
Increased serum lithium concentrations and toxicity. Monitor lithium levels.
Diuretics
Increased risk of hypotension, especially with initial doses.
NSAIDs (e.g., Ibuprofen)
May reduce antihypertensive effect and increase risk of renal impairment, especially in elderly or dehydrated patients.
Potassium-sparing diuretics/Potassium supplements
Increased risk of hyperkalemia. Monitor serum potassium levels.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include hypotension, dizziness, and tachycardia; bradycardia may occur. Treatment is symptomatic and supportive. If ingestion is recent, gastric lavage or activated charcoal may be considered.
Pregnancy & Lactation
Pregnancy Category D. Contraindicated during pregnancy, especially in the 2nd and 3rd trimesters, due to risk of fetal injury or death. Not recommended during lactation as it is unknown if it is excreted in breast milk.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from manufacturing date
Availability
Pharmacies, hospitals
Approval Status
Approved (hypothetical)
Patent Status
Patented (hypothetical)
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Global Brand Names
International brand names for this medicine
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