Itchnil
Generic Name
Clobetasol Propionate + Neomycin Sulfate + Miconazole Nitrate
Manufacturer
XYZ Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| itchnil 1 3 cream | ৳ 95.00 | N/A |
Description
Overview of the medicine
Itchnil-1-3-cream is a topical preparation containing a potent corticosteroid, an antibiotic, and an antifungal agent, used for the treatment of inflammatory skin conditions complicated by bacterial and/or fungal infections.
Uses & Indications
Dosage
Adults
Apply a thin layer to the affected skin area twice daily for up to 2 weeks. Do not use for more than 4 weeks without medical review.
Elderly
Same as adult dosage, but use with caution due to thinner skin and potential for increased systemic absorption.
Renal_impairment
No specific dosage adjustment required for topical application, but caution with extensive use.
How to Take
For external use only. Wash and dry the affected area. Apply a thin film of cream and gently rub it in. Avoid contact with eyes, mouth, and other mucous membranes. Do not use on open wounds or broken skin unless directed by a doctor. Wash hands after application.
Mechanism of Action
Clobetasol Propionate acts as a potent corticosteroid, suppressing inflammation, itching, and vasoconstriction. Neomycin Sulfate is an aminoglycoside antibiotic that inhibits bacterial protein synthesis. Miconazole Nitrate is an imidazole antifungal that inhibits ergosterol synthesis, essential for fungal cell membranes.
Pharmacokinetics
Onset
Relief of symptoms typically within a few days of initiation.
Excretion
Excreted mainly via urine and bile if systemically absorbed.
Half life
Systemic half-life not precisely defined for topical use; local effects persist for several hours.
Absorption
Minimal systemic absorption through intact skin; increased absorption with skin damage, occlusion, or prolonged use, especially in children.
Metabolism
Metabolized primarily in the liver if systemically absorbed.
Side Effects
Contraindications
- Hypersensitivity to Clobetasol Propionate, Neomycin Sulfate, Miconazole Nitrate, or any other component of the cream
- Viral skin infections (e.g., herpes simplex, varicella)
- Tuberculous or syphilitic lesions of the skin
- Acne rosacea, perioral dermatitis
- Vaccination reactions
Drug Interactions
Systemic corticosteroids
Increased risk of systemic corticosteroid side effects.
Other topical corticosteroids
Concurrent use may increase systemic absorption and risk of side effects.
Storage
Store below 30°C, in a cool and dry place, away from direct sunlight. Do not freeze.
Overdose
Acute overdose is unlikely with topical use. Chronic overdose or extensive application can lead to systemic effects of corticosteroids (e.g., Cushing's syndrome) or ototoxicity (with Neomycin). Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy and lactation only if the potential benefit outweighs the potential risk to the fetus/infant. Consult a doctor. Avoid applying to large areas or for prolonged periods.
Side Effects
Contraindications
- Hypersensitivity to Clobetasol Propionate, Neomycin Sulfate, Miconazole Nitrate, or any other component of the cream
- Viral skin infections (e.g., herpes simplex, varicella)
- Tuberculous or syphilitic lesions of the skin
- Acne rosacea, perioral dermatitis
- Vaccination reactions
Drug Interactions
Systemic corticosteroids
Increased risk of systemic corticosteroid side effects.
Other topical corticosteroids
Concurrent use may increase systemic absorption and risk of side effects.
Storage
Store below 30°C, in a cool and dry place, away from direct sunlight. Do not freeze.
Overdose
Acute overdose is unlikely with topical use. Chronic overdose or extensive application can lead to systemic effects of corticosteroids (e.g., Cushing's syndrome) or ototoxicity (with Neomycin). Treatment is symptomatic and supportive.
Pregnancy & Lactation
Use during pregnancy and lactation only if the potential benefit outweighs the potential risk to the fetus/infant. Consult a doctor. Avoid applying to large areas or for prolonged periods.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date
Availability
Pharmacies, drugstores
Approval Status
Approved by relevant national drug authorities (e.g., DGDA)
Patent Status
Generically available
Clinical Trials
Clinical trials typically support the efficacy and safety of its individual components and their common combinations for various dermatological conditions.
Lab Monitoring
- No routine lab monitoring required for typical topical use.
- For extensive or prolonged use, monitoring for adrenal suppression may be considered.
Doctor Notes
- Educate patients on proper application technique and duration.
- Advise against using on the face, groin, or axillae for prolonged periods.
- Monitor for signs of skin atrophy or systemic absorption, especially in children or with extensive use.
Patient Guidelines
- Use exactly as prescribed by your doctor.
- Do not cover the treated area with bandages or dressings unless advised by your doctor.
- Do not use for longer than the prescribed duration.
- Avoid applying near the eyes or to the face unless specifically directed.
Missed Dose Advice
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not apply extra cream to make up for a missed dose.
Driving Precautions
Itchnil-1-3-cream is a topical preparation and is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Keep the affected skin clean and dry.
- Avoid irritants that may worsen the condition.
- Wear loose-fitting clothing to prevent friction on the treated area.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.