Januvia
Generic Name
Sitagliptin
Manufacturer
Merck Sharp & Dohme
Country
USA
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Description
Overview of the medicine
Sitagliptin is a DPP-4 inhibitor used to treat type 2 diabetes.
Uses & Indications
Dosage
Adults
100 mg once daily
Elderly
100 mg once daily, adjust for renal function
Renal_impairment
Adjust dose based on creatinine clearance: CrCl 30-50 mL/min: 50 mg once daily, CrCl < 30 mL/min: 25 mg once daily
How to Take
Orally, with or without food
Mechanism of Action
Inhibits DPP-4 enzyme, increasing incretin levels and insulin secretion.
Pharmacokinetics
Onset
Within 1-2 hours
Excretion
Renal excretion
Half life
Approximately 12 hours
Absorption
Rapidly absorbed, bioavailability ~87%
Metabolism
Limited hepatic metabolism
Side Effects
Contraindications
- •Hypersensitivity to sitagliptin
- •Type 1 Diabetes
Drug Interactions
Digoxin
May increase digoxin levels
Insulin
Increased risk of hypoglycemia
Storage
Store at room temperature (15-30°C)
Overdose
Supportive and symptomatic treatment
Pregnancy & Lactation
Use during pregnancy only if clearly needed. Caution advised during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months
Availability
Pharmacies
Approval Status
FDA Approved
Patent Status
Expired
WHO Essential Medicine
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Global Brand Names
International brand names for this medicine
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