Joinflex-M
Generic Name
Glucosamine Sulfate + Chondroitin Sulfate + MSM
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| joinflex m 20 mg tablet | ৳ 25.00 | ৳ 150.00 |
Description
Overview of the medicine
Joinflex-M is a nutritional supplement combining Glucosamine Sulfate, Chondroitin Sulfate, and Methylsulfonylmethane (MSM). It is used to support joint health, reduce joint pain, and improve mobility, primarily for conditions like osteoarthritis.
Uses & Indications
Dosage
Adults
Typically 1-2 tablets daily, preferably with meals. Dosage may vary based on product strength and physician's advice.
Elderly
No specific dosage adjustment required; generally same as adults unless severe renal or hepatic impairment exists.
Renal_impairment
Use with caution in severe renal impairment. Consult a physician for appropriate dosing.
How to Take
Take orally with a glass of water, preferably with meals to minimize gastrointestinal upset. Do not chew or crush the tablet.
Mechanism of Action
Glucosamine helps in the synthesis of cartilage components. Chondroitin contributes to cartilage elasticity and inhibits enzymes that degrade cartilage. MSM provides sulfur, essential for connective tissue, and has anti-inflammatory properties.
Pharmacokinetics
Onset
Therapeutic effects typically begin after 2-4 weeks, with full benefits observed after 2-3 months.
Excretion
Glucosamine: Primarily via urine and feces. Chondroitin: Primarily via urine. MSM: Primarily via urine.
Half life
Glucosamine: ~15-18 hours. Chondroitin: ~5-6 hours. MSM: ~10-12 hours.
Absorption
Glucosamine: High oral bioavailability (~90%). Chondroitin: Low oral bioavailability (~15-20%). MSM: Readily absorbed from the gastrointestinal tract.
Metabolism
Glucosamine: Partially metabolized in the liver. Chondroitin: Metabolized in the liver and intestinal flora. MSM: Primarily excreted unchanged or as inactive metabolites.
Side Effects
Contraindications
- Known hypersensitivity to Glucosamine, Chondroitin, MSM, or any other component of the formulation.
- Allergy to shellfish (as glucosamine is often derived from shellfish).
- Severe liver or kidney disease (use with caution).
Drug Interactions
Warfarin
Glucosamine may enhance the effect of anticoagulants like warfarin, potentially increasing INR and bleeding risk. Close monitoring of INR is recommended.
Tetracyclines
Chondroitin may increase the absorption of tetracyclines.
Insulin/Antidiabetic agents
Glucosamine may affect glucose metabolism, potentially altering the effectiveness of insulin or antidiabetic drugs. Monitor blood glucose levels.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose is unlikely to cause severe toxicity. Symptoms may include gastrointestinal upset (nausea, vomiting, diarrhea). Treatment is symptomatic and supportive.
Pregnancy & Lactation
Not recommended during pregnancy and lactation due to insufficient data on safety. Use only if clearly needed and under strict medical supervision.
Side Effects
Contraindications
- Known hypersensitivity to Glucosamine, Chondroitin, MSM, or any other component of the formulation.
- Allergy to shellfish (as glucosamine is often derived from shellfish).
- Severe liver or kidney disease (use with caution).
Drug Interactions
Warfarin
Glucosamine may enhance the effect of anticoagulants like warfarin, potentially increasing INR and bleeding risk. Close monitoring of INR is recommended.
Tetracyclines
Chondroitin may increase the absorption of tetracyclines.
Insulin/Antidiabetic agents
Glucosamine may affect glucose metabolism, potentially altering the effectiveness of insulin or antidiabetic drugs. Monitor blood glucose levels.
Storage
Store in a cool and dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Overdose is unlikely to cause severe toxicity. Symptoms may include gastrointestinal upset (nausea, vomiting, diarrhea). Treatment is symptomatic and supportive.
Pregnancy & Lactation
Not recommended during pregnancy and lactation due to insufficient data on safety. Use only if clearly needed and under strict medical supervision.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months (2-3 years) from manufacturing date
Availability
Available in pharmacies and drugstores
Approval Status
DGDA approved as a dietary supplement
Patent Status
Generally off-patent for individual components
Clinical Trials
Numerous clinical trials have been conducted on individual components and their combinations, generally supporting their efficacy in reducing osteoarthritis symptoms, though results can be varied.
Lab Monitoring
- Routine lab monitoring is not typically required. In patients on warfarin, INR monitoring is crucial.
- Monitor blood glucose in diabetic patients.
Doctor Notes
- Advise patients that full therapeutic effects may take several weeks to months.
- Counsel patients on potential interactions, especially with anticoagulants.
- Emphasize that this is a supplement and not a replacement for prescribed medication for severe conditions.
Patient Guidelines
- Take the medicine regularly as prescribed by your doctor or as indicated on the label.
- Do not exceed the recommended dose.
- Inform your doctor about any existing medical conditions or other medications you are taking.
- Results may take several weeks to appear.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Joinflex-M is generally not expected to impair the ability to drive or operate machinery. However, if you experience dizziness or drowsiness, avoid such activities.
Lifestyle Advice
- Maintain a healthy weight to reduce stress on joints.
- Engage in regular low-impact exercise suitable for joint health.
- Adopt a balanced diet rich in anti-inflammatory foods.
- Avoid prolonged standing or activities that exacerbate joint pain.
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