Joingurd
Generic Name
Glucosamine Sulfate + Chondroitin Sulfate
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| joingurd 250 mg tablet | ৳ 8.00 | ৳ 32.00 |
Description
Overview of the medicine
Joingurd is a dietary supplement containing Glucosamine Sulfate and Chondroitin Sulfate, often used to support joint health, reduce joint pain, and improve mobility in individuals with osteoarthritis.
Uses & Indications
Dosage
Adults
One tablet daily, preferably with meals, or as directed by a physician.
Elderly
No specific dosage adjustment required, but caution is advised in individuals with comorbidities.
Renal_impairment
Use with caution; dose adjustment may be necessary in severe renal impairment, consult a physician.
How to Take
Take orally with a glass of water, preferably with a meal to minimize gastrointestinal upset. Do not crush or chew the tablet.
Mechanism of Action
Glucosamine is a precursor for glycosaminoglycans (GAGs), a major component of cartilage. It may help in cartilage repair and regeneration. Chondroitin Sulfate is also a GAG that helps retain water in the cartilage, improving its elasticity and shock-absorbing properties. Both are thought to have mild anti-inflammatory effects.
Pharmacokinetics
Onset
Symptomatic relief usually observed after 2-4 weeks of consistent use, with maximal effects after several months.
Excretion
Primarily renal excretion for both, with some fecal excretion.
Half life
Glucosamine: ~15 hours; Chondroitin: ~6 hours (variable depending on formulation and individual).
Absorption
Glucosamine has an oral bioavailability of about 25-30%. Chondroitin sulfate has an oral bioavailability of about 15-20%.
Metabolism
Glucosamine is primarily metabolized in the liver. Chondroitin is largely metabolized by lysosomal enzymes.
Side Effects
Contraindications
- Hypersensitivity to glucosamine, chondroitin, or any excipients
- Shellfish allergy (glucosamine is often derived from shellfish)
- Pregnancy and lactation (insufficient data)
Drug Interactions
Warfarin
May potentiate the effect of warfarin, increasing the risk of bleeding. Close monitoring of INR is advised.
Tetracycline antibiotics
Glucosamine may increase the absorption of tetracyclines.
Anti-diabetic medications
Glucosamine may affect blood glucose levels, requiring careful monitoring in diabetic patients.
Storage
Store in a cool, dry place below 30°C, away from direct sunlight and moisture. Keep out of reach of children.
Overdose
Overdose is rare. Symptoms might include nausea, vomiting, diarrhea, or constipation. Treatment is symptomatic and supportive.
Pregnancy & Lactation
Not recommended during pregnancy or lactation due to insufficient data on safety. Consult a doctor before use.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 to 36 months from the date of manufacture.
Availability
Pharmacies, drugstores, health food stores
Approval Status
Approved as a supplement/nutraceutical
Patent Status
Generic versions available, original patents likely expired or not applicable for combinations of common ingredients
Clinical Trials
Numerous clinical trials have investigated the efficacy of glucosamine and chondroitin for osteoarthritis, with mixed results. Some studies show modest benefits for pain and function, while others show no significant difference from placebo.
Lab Monitoring
- Blood glucose levels (for diabetic patients)
- INR (for patients on warfarin)
Doctor Notes
- Advise patients that benefits are usually gradual and not immediate.
- Emphasize lifestyle modifications (weight management, exercise) alongside supplementation.
- Caution patients on warfarin or with diabetes about potential interactions/monitoring needs.
Patient Guidelines
- Take regularly for at least 2-3 months to assess efficacy.
- Inform your doctor about all medications and supplements you are taking.
- Discontinue use and consult a doctor if severe allergic reactions occur.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Generally none, as it does not typically cause drowsiness or impair mental alertness. If drowsiness occurs, avoid driving.
Lifestyle Advice
- Maintain a healthy weight to reduce joint stress.
- Engage in low-impact exercises like swimming or cycling.
- Eat a balanced diet rich in anti-inflammatory foods.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.