kalcoral-kit
Generic Name
Calcium Carbonate + Cholecalciferol (Vitamin D3)
Manufacturer
General Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| kalcoral kit 150 mg tablet | ৳ 2,150.00 | N/A |
Description
Overview of the medicine
Kalcoral-kit is a supplement combining Calcium Carbonate and Vitamin D3, essential for bone health, preventing and treating conditions associated with calcium deficiency and promoting proper bone mineralization.
Uses & Indications
Dosage
Adults
Typically 1-2 tablets daily, or as directed by the physician. It is recommended to take with or after meals for better absorption.
Elderly
Similar to adult dosage; caution and monitoring for hypercalcemia should be exercised.
Renal_impairment
Use with caution. Dosage adjustment may be required based on serum calcium and phosphate levels, and renal function. Consult a physician.
How to Take
Take orally, swallowed whole with a glass of water. Can be taken with or after meals to enhance absorption and reduce gastric upset.
Mechanism of Action
Calcium is a vital mineral required for bone formation, maintenance, and various metabolic processes. Vitamin D3 facilitates the absorption of calcium from the gastrointestinal tract and its deposition into bones, helping to regulate calcium and phosphate levels in the body.
Pharmacokinetics
Onset
Therapeutic effects on bone density are gradual, taking weeks to months.
Excretion
Unabsorbed calcium is excreted in feces. Absorbed calcium is mainly excreted via kidneys in urine, with some fecal excretion. Vitamin D3 metabolites are primarily excreted in bile and feces.
Half life
Elemental calcium has complex pharmacokinetics; Vitamin D3 has a half-life of about 15-20 hours for the parent compound, while its active metabolite (calcitriol) has a half-life of several days.
Absorption
Calcium Carbonate is absorbed from the gastrointestinal tract, with absorption efficiency varying. Vitamin D3 is absorbed from the small intestine, primarily in the presence of bile salts and fat.
Metabolism
Calcium is not extensively metabolized. Vitamin D3 is hydroxylated in the liver to 25-hydroxyvitamin D3 (calcifediol) and then in the kidneys to 1,25-dihydroxyvitamin D3 (calcitriol), its active form.
Side Effects
Contraindications
- Hypersensitivity to any component of the formulation
- Hypercalcemia (high calcium levels in blood)
- Hypercalciuria (high calcium levels in urine)
- Severe renal impairment
- Kidney stones (nephrolithiasis) or history of kidney stones
Drug Interactions
Corticosteroids
Can decrease calcium absorption and may require an increase in calcium/Vitamin D dosage.
Thiazide diuretics
May reduce calcium excretion, increasing the risk of hypercalcemia.
Cardiac glycosides (e.g., Digoxin)
Hypercalcemia can potentiate the effects of cardiac glycosides, increasing the risk of toxicity (arrhythmias).
Thyroid hormones (e.g., Levothyroxine)
Calcium can impair the absorption of thyroid hormones. Separate administration by at least 4 hours.
Tetracycline and Fluoroquinolone antibiotics
Calcium can form insoluble complexes with these antibiotics, reducing their absorption. Administer calcium at least 2 hours before or 4-6 hours after these antibiotics.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose (hypercalcemia) include nausea, vomiting, constipation, thirst, polyuria (frequent urination), muscle weakness, confusion, and in severe cases, kidney damage and cardiac arrhythmias. Management involves discontinuation of the supplement, hydration, and medical intervention to lower calcium levels.
Pregnancy & Lactation
Calcium and Vitamin D are essential during pregnancy and lactation. This kit can be used under medical supervision to ensure adequate intake, avoiding excessive dosages.
Side Effects
Contraindications
- Hypersensitivity to any component of the formulation
- Hypercalcemia (high calcium levels in blood)
- Hypercalciuria (high calcium levels in urine)
- Severe renal impairment
- Kidney stones (nephrolithiasis) or history of kidney stones
Drug Interactions
Corticosteroids
Can decrease calcium absorption and may require an increase in calcium/Vitamin D dosage.
Thiazide diuretics
May reduce calcium excretion, increasing the risk of hypercalcemia.
Cardiac glycosides (e.g., Digoxin)
Hypercalcemia can potentiate the effects of cardiac glycosides, increasing the risk of toxicity (arrhythmias).
Thyroid hormones (e.g., Levothyroxine)
Calcium can impair the absorption of thyroid hormones. Separate administration by at least 4 hours.
Tetracycline and Fluoroquinolone antibiotics
Calcium can form insoluble complexes with these antibiotics, reducing their absorption. Administer calcium at least 2 hours before or 4-6 hours after these antibiotics.
Storage
Store in a cool, dry place below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose (hypercalcemia) include nausea, vomiting, constipation, thirst, polyuria (frequent urination), muscle weakness, confusion, and in severe cases, kidney damage and cardiac arrhythmias. Management involves discontinuation of the supplement, hydration, and medical intervention to lower calcium levels.
Pregnancy & Lactation
Calcium and Vitamin D are essential during pregnancy and lactation. This kit can be used under medical supervision to ensure adequate intake, avoiding excessive dosages.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture.
Availability
Available in pharmacies and drugstores
Approval Status
Approved by DGDA (Bangladesh)
Patent Status
Off-patent
Clinical Trials
Numerous clinical trials have demonstrated the efficacy of calcium and Vitamin D supplementation in improving bone mineral density and reducing fracture risk, particularly in elderly and postmenopausal women.
Lab Monitoring
- Serum calcium levels (especially in patients with renal impairment or on long-term therapy)
- Urinary calcium excretion (to monitor for hypercalciuria)
- Renal function (creatinine, BUN)
Doctor Notes
- Advise patients to maintain adequate hydration to prevent kidney stones.
- Caution in patients with pre-existing renal impairment or a history of kidney stones.
- Monitor serum calcium and vitamin D levels periodically in patients on long-term therapy.
- Educate patients on potential drug interactions, especially with antibiotics and thyroid hormones.
Patient Guidelines
- Do not exceed the recommended dose without consulting your doctor.
- Inform your doctor about all other medications and supplements you are taking.
- Report any unusual or severe side effects to your healthcare provider.
- Maintain a balanced diet and adequate fluid intake.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
This medicine is not known to affect the ability to drive or operate machinery.
Lifestyle Advice
- Engage in regular weight-bearing exercise to support bone density.
- Ensure adequate sunlight exposure for natural Vitamin D synthesis, while also protecting skin from excessive sun.
- Avoid smoking and excessive alcohol consumption, as these can negatively impact bone health.
- Maintain a diet rich in calcium and Vitamin D from natural sources where possible.
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