Kanopas
Generic Name
Pantoprazole Sodium
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| kanopas 20 mg tablet | ৳ 120.00 | ৳ 1,200.00 |
Description
Overview of the medicine
Kanopas 20 mg tablet contains Pantoprazole, a proton pump inhibitor (PPI) used to treat conditions where there is too much acid in the stomach, such as gastroesophageal reflux disease (GERD), erosive esophagitis, and Zollinger-Ellison syndrome. It works by reducing the amount of acid your stomach makes.
Uses & Indications
Dosage
Adults
For GERD: 20-40 mg once daily for up to 8 weeks. For Erosive Esophagitis: 40 mg once daily for up to 8 weeks. For Zollinger-Ellison Syndrome: Initial dose 40 mg twice daily, adjusted based on response.
Elderly
No dosage adjustment generally required, but caution is advised in patients with severe hepatic impairment.
Renal_impairment
No dosage adjustment required for renal impairment or hemodialysis.
How to Take
Take orally, typically once daily, before a meal (preferably in the morning). Swallow the tablet whole with water; do not chew or crush it.
Mechanism of Action
Pantoprazole is a proton pump inhibitor that irreversibly binds to the H+/K+-ATPase enzyme system (the 'proton pump') in the gastric parietal cells, thereby inhibiting the final step in gastric acid secretion. This leads to a sustained decrease in gastric acid production.
Pharmacokinetics
Onset
Within 1 hour (antisecretory effect)
Excretion
Mainly excreted renally (approximately 80%) as metabolites, with the remainder excreted in feces.
Half life
Approximately 1 hour (terminal half-life), but the duration of acid suppression is much longer due to irreversible binding to the proton pump.
Absorption
Rapidly absorbed after oral administration; bioavailability is about 77%. Peak plasma concentrations are achieved in approximately 2 to 2.5 hours.
Metabolism
Extensively metabolized in the liver, primarily by the cytochrome P450 (CYP) enzyme system, mainly CYP2C19 and CYP3A4. Main metabolite is desmethylpantoprazole.
Side Effects
Contraindications
- Hypersensitivity to pantoprazole, other substituted benzimidazoles, or any component of the formulation.
- Patients with known severe liver disease may require caution.
Drug Interactions
Warfarin
Increased INR and prothrombin time, monitor carefully.
Clopidogrel
Potential reduction in clopidogrel's antiplatelet effect, consider alternative PPIs or antiplatelet therapy.
Methotrexate
Possible increased methotrexate levels, especially with high doses.
Drugs dependent on gastric pH (e.g., ketoconazole, atazanavir)
Reduced absorption due to increased gastric pH.
Storage
Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.
Overdose
Symptoms of overdose are generally mild and include lethargy, drowsiness, tachycardia, nausea, vomiting, and diarrhea. Treatment is symptomatic and supportive. Pantoprazole is not readily dialyzable.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Small amounts of pantoprazole have been detected in breast milk; a decision should be made whether to discontinue nursing or the drug, taking into account the importance of the drug to the mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Usually 2-3 years from the date of manufacture.
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities (e.g., DGDA)
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Extensive clinical trials have demonstrated pantoprazole's efficacy and safety in various acid-related disorders. Ongoing research continues to explore its long-term effects and potential new indications.
Lab Monitoring
- Monitor magnesium levels with long-term use (especially >1 year).
- Monitor INR/PT if co-administered with warfarin.
- Monitor liver function tests in patients with hepatic impairment.
Doctor Notes
- Counsel patients on potential long-term risks with PPI use.
- Consider lowest effective dose for the shortest duration.
- Review concomitant medications, especially those affecting gastric pH or interacting with CYP2C19/3A4.
Patient Guidelines
- Take the tablet whole with water, do not chew or crush.
- Take approximately 30-60 minutes before a meal for best results.
- Do not stop taking the medicine suddenly without consulting your doctor.
- Inform your doctor about all other medications you are taking, including over-the-counter drugs and herbal supplements.
Missed Dose Advice
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
Driving Precautions
Pantoprazole generally does not affect the ability to drive or operate machinery. However, if you experience dizziness or visual disturbances, avoid such activities.
Lifestyle Advice
- Avoid foods and drinks that trigger your symptoms (e.g., spicy foods, caffeine, alcohol).
- Eat smaller, more frequent meals.
- Avoid lying down immediately after eating.
- Elevate the head of your bed.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.