Take orally with food or milk to minimize gastrointestinal upset. Swallow the tablet whole; do not crush, chew, or break extended-release tablets.

Ketoprofen inhibits prostaglandin synthesis by blocking cyclooxygenase (COX-1 and COX-2) enzymes. Prostaglandins are mediators of pain, inflammation, and fever, so their inhibition leads to the therapeutic effects.

• •Hypersensitivity to ketoprofen, aspirin, or other NSAIDs
• •Active gastrointestinal bleeding or peptic ulcer
• •Severe heart failure
• •Severe renal or hepatic impairment
• •Third trimester of pregnancy

Store below 30°C in a dry place, away from light and moisture. Keep out of reach of children.

Symptoms may include drowsiness, nausea, vomiting, epigastric pain, GI bleeding, hypotension, and respiratory depression. Management involves supportive care, gastric lavage, activated charcoal, and symptomatic treatment. There is no specific antidote.

Avoid in the third trimester of pregnancy due to risk of premature closure of the fetal ductus arteriosus and renal dysfunction. Use with caution in the first and second trimesters only if potential benefit outweighs risk. Excreted in breast milk; use with caution during lactation, or consider alternatives.