Ketocure
Generic Name
Ketoconazole
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ketocure 1 mg syrup | ৳ 72.00 | N/A |
| ketocure 1 mg tablet | ৳ 3.00 | ৳ 30.00 |
Description
Overview of the medicine
Ketocure contains Ketoconazole, an antifungal agent used to treat various fungal skin infections such as tinea infections, candidiasis, pityriasis versicolor, and seborrheic dermatitis.
Uses & Indications
Dosage
Adults
For cream: Apply to affected areas once daily for 2-4 weeks. For shampoo: Apply to wet scalp/affected areas, lather, leave for 3-5 minutes, then rinse thoroughly. Use twice weekly for 2-4 weeks for seborrheic dermatitis, then once weekly as maintenance if needed.
Elderly
No specific dose adjustment required for topical use.
Renal_impairment
No specific dose adjustment required for topical use.
How to Take
For topical use only. Apply a thin layer of cream to the affected skin and surrounding areas. For shampoo, apply to wet hair/affected areas, gently massage, leave for 3-5 minutes, then rinse thoroughly. Ensure to wash hands before and after application.
Mechanism of Action
Ketoconazole inhibits the synthesis of ergosterol, a vital component of fungal cell membranes, leading to increased membrane permeability and leakage of cellular contents, ultimately causing fungal cell death.
Pharmacokinetics
Onset
Clinical improvement usually seen within 2-4 weeks for most skin infections. For seborrheic dermatitis, improvement may be observed earlier.
Excretion
Not significant systemically after topical use.
Half life
Not well characterized for topical use due to minimal systemic absorption.
Absorption
Minimal systemic absorption after topical application on intact skin.
Metabolism
Not significant systemically after topical use.
Side Effects
Contraindications
- Hypersensitivity to ketoconazole or any component of the formulation.
- Oral ketoconazole is contraindicated in patients with acute or chronic liver disease.
Drug Interactions
Systemic absorption of topical ketoconazole is minimal, therefore systemic drug interactions are unlikely to occur.
No specific drug interactions are commonly reported for topical ketoconazole. However, caution is advised if applied concurrently with other topical products.
Storage
Store below 30°C in a dry place, away from direct sunlight and moisture. Keep out of reach of children. Do not freeze.
Overdose
Overdose with topical application is unlikely. Accidental ingestion of topical formulation may cause gastrointestinal discomfort (nausea, vomiting, abdominal pain); seek medical advice if large quantities are ingested.
Pregnancy & Lactation
Pregnancy Category C. Use only if clearly needed after consulting a doctor. Minimal absorption with topical use, but caution is advised. Consult your doctor if breastfeeding, as it is unknown whether ketoconazole is excreted in breast milk after topical application.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from the date of manufacture, specific details on packaging.
Availability
Pharmacies, drugstores
Approval Status
Approved by DGDA
Patent Status
Generic available
WHO Essential Medicine
YesClinical Trials
Ketoconazole has undergone extensive clinical trials establishing its efficacy and safety profile for topical use in various fungal skin conditions. Studies demonstrate significant mycological and clinical cure rates.
Lab Monitoring
- Not generally required for topical ketoconazole due to minimal systemic absorption.
Doctor Notes
- Emphasize to patients the importance of completing the full course of treatment, even if symptoms improve quickly, to prevent recurrence.
- Advise patients on proper hygiene and avoidance of factors that promote fungal growth to prevent re-infection.
- For oral ketoconazole, monitor liver function tests regularly due to the risk of hepatotoxicity.
Patient Guidelines
- Wash hands before and after application.
- Do not apply to open wounds, cuts, or irritated skin.
- Avoid contact with eyes, nose, mouth, and other mucous membranes.
- Complete the full course of treatment even if symptoms improve to prevent recurrence.
- Report any severe irritation or allergic reaction to your doctor.
Missed Dose Advice
Apply as soon as remembered. If it's almost time for the next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not apply double the amount to make up for a missed dose.
Driving Precautions
Topical Ketocure is not expected to affect the ability to drive or operate machinery.
Lifestyle Advice
- Keep affected area clean and dry.
- Avoid tight clothing or footwear that can trap moisture and promote fungal growth.
- Wear breathable fabrics like cotton.
- Share personal items (towels, combs, hats) to prevent spreading infection.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.