Ketof
Generic Name
Ketotifen Fumarate Ophthalmic Solution 0.025%
Manufacturer
Incepta Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
Variant | Unit Price | Strip Price |
---|---|---|
ketof 0025 eye drop | ৳ 100.00 | N/A |
Description
Overview of the medicine
Ketotifen Fumarate Ophthalmic Solution is an antihistamine eye drop used for the temporary prevention and relief of ocular itching due to allergic conjunctivitis.
Uses & Indications
Dosage
Adults
One drop in the affected eye(s) twice daily (every 8 to 12 hours).
Elderly
Same as adults.
Renal_impairment
No adjustment needed for topical ocular use.
How to Take
For ophthalmic use only. Tilt head back, pull down lower eyelid, and instill one drop into the conjunctival sac. Avoid touching the tip of the dropper to the eye or any other surface.
Mechanism of Action
Ketotifen is a relatively selective, non-competitive H1-receptor antagonist and mast cell stabilizer. It inhibits the release of inflammatory mediators such as histamine from mast cells, thereby reducing allergic reactions.
Pharmacokinetics
Onset
Within minutes.
Excretion
Primarily excreted unchanged or as metabolites.
Half life
Not well defined for ocular, but systemic ~12 hours.
Absorption
Minimal systemic absorption after ocular administration.
Metabolism
Minor metabolism.
Side Effects
Contraindications
- Hypersensitivity to ketotifen fumarate or any component of the formulation
Drug Interactions
None known
No significant systemic drug interactions are expected with ophthalmic administration due to minimal systemic absorption.
Storage
Store at controlled room temperature (15°C to 25°C or 59°F to 77°F). Protect from light. Do not freeze.
Overdose
Ocular overdose is unlikely to lead to significant systemic effects. If accidentally ingested, standard measures to remove unabsorbed drug should be considered.
Pregnancy & Lactation
Pregnancy Category C. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether ketotifen is excreted in human breast milk; caution should be exercised when administered to a nursing mother.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24-36 months (unopened). Discard 28 days after opening.
Availability
Available in pharmacies and hospitals
Approval Status
DGDA/FDA Approved
Patent Status
Off-patent (Generic available)
Clinical Trials
Extensive clinical trials have demonstrated the efficacy and safety of ketotifen fumarate ophthalmic solution in the treatment of ocular itching associated with allergic conjunctivitis. Studies typically show rapid onset of action and sustained relief.
Lab Monitoring
- Not typically required for topical ophthalmic use.
Doctor Notes
- Educate patients on proper instillation technique to avoid contamination and maximize efficacy.
- Advise patients about potential for transient blurred vision immediately after application.
- Ensure patients understand that this is for allergic itching and not for infections.
Patient Guidelines
- Do not wear contact lenses if your eyes are red.
- If you wear contact lenses, remove them before applying the drops and wait at least 10 minutes before reinserting them.
- Do not touch the dropper tip to your eye or any other surface to avoid contamination.
- Keep bottle tightly closed when not in use.
Missed Dose Advice
If a dose is missed, apply it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
May cause temporary blurred vision or mild ocular irritation immediately after instillation. Patients should be advised to wait until vision clears before driving or operating machinery.
Lifestyle Advice
- Avoid known allergens that trigger allergic conjunctivitis (e.g., pollen, dust mites, pet dander).
- Maintain good eye hygiene.
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Global Brand Names
International brand names for this medicine
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