Ketoplex
Generic Name
Ketoplex
Manufacturer
Global Pharma Inc.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ketoplex 10 mg tablet | ৳ 20.00 | ৳ 200.00 |
Description
Overview of the medicine
Ketoplex 10 mg Tablet is a non-steroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce inflammation, and lower fever. It is typically prescribed for mild to moderate pain conditions.
Uses & Indications
Dosage
Adults
10 mg orally, 2-3 times daily, or as directed by physician. Max daily dose typically 30 mg.
Elderly
Initiate with the lowest effective dose; dosage adjustment may be necessary due to potential renal or hepatic impairment. Max 20 mg daily.
Renal_impairment
Use with caution; dose reduction may be required based on creatinine clearance. Avoid in severe renal impairment.
How to Take
Take orally with food or milk to minimize gastrointestinal upset. Swallow the tablet whole with a glass of water; do not crush or chew.
Mechanism of Action
Ketoplex inhibits the activity of cyclooxygenase (COX-1 and COX-2) enzymes, which are responsible for the synthesis of prostaglandins. Prostaglandins are mediators of pain, inflammation, and fever. By inhibiting their synthesis, Ketoplex reduces these symptoms.
Pharmacokinetics
Onset
Analgesic effect observed within 30-60 minutes; anti-inflammatory effects may take longer, up to 1-2 weeks for chronic conditions.
Excretion
Mainly excreted by the kidneys (approximately 60%) and some via bile (approximately 30%).
Half life
Approximately 4-6 hours.
Absorption
Well absorbed from the gastrointestinal tract following oral administration, with peak plasma concentrations reached within 1-2 hours.
Metabolism
Primarily metabolized in the liver via cytochrome P450 enzymes (e.g., CYP2C9) to inactive metabolites.
Side Effects
Contraindications
- Hypersensitivity to Ketoplex or other NSAIDs
- History of asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
- Active gastrointestinal bleeding or ulceration
- Severe renal or hepatic impairment
- Last trimester of pregnancy
- Severe heart failure
Drug Interactions
SSRIs
Increased risk of gastrointestinal bleeding.
Lithium
Increased plasma lithium levels, leading to toxicity.
Methotrexate
Increased methotrexate toxicity.
Warfarin, Heparin
Increased risk of bleeding.
Diuretics, ACE inhibitors
Reduced hypotensive effect and increased risk of renal impairment.
Storage
Store in a cool, dry place, below 30°C. Protect from light and moisture. Keep out of reach of children.
Overdose
Symptoms may include nausea, vomiting, epigastric pain, lethargy, and drowsiness. Management involves symptomatic and supportive care, gastric lavage, activated charcoal, and monitoring of vital signs.
Pregnancy & Lactation
Not recommended during the third trimester of pregnancy due to potential fetal harm (premature closure of ductus arteriosus). Use during early pregnancy or lactation only if clearly needed and benefits outweigh risks, under strict medical supervision.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
24 months from manufacturing date.
Availability
Pharmacies, hospitals, clinics
Approval Status
Approved by regulatory bodies (e.g., FDA, DGDA)
Patent Status
Patent pending (hypothetical)
WHO Essential Medicine
YesClinical Trials
Phase III clinical trials demonstrated efficacy in reducing mild to moderate pain with a favorable safety profile. Post-marketing surveillance ongoing.
Lab Monitoring
- Complete blood count (CBC)
- Renal function tests (Creatinine, BUN)
- Liver function tests (ALT, AST)
- Blood pressure monitoring
Doctor Notes
- Prescribe the lowest effective dose for the shortest duration necessary.
- Monitor patients for signs of GI bleeding and cardiovascular events.
- Caution in patients with hypertension, heart failure, and renal impairment.
- Advise patients on proper administration and potential side effects.
Patient Guidelines
- Take with food to minimize stomach upset.
- Do not exceed the recommended dose.
- Inform your doctor about all other medications you are taking.
- Report any signs of gastrointestinal bleeding immediately.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose.
Driving Precautions
Ketoplex may cause dizziness or drowsiness in some individuals. If you experience these effects, avoid driving or operating heavy machinery.
Lifestyle Advice
- Maintain a healthy diet.
- Stay hydrated.
- Avoid smoking and excessive alcohol consumption.
- Engage in regular, moderate exercise if appropriate for your condition.
Alternative Medicines in Bangladesh
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.