Ketovir
Generic Name
Ketovir
Manufacturer
PharmaCorp Global
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| ketovir 10 mg tablet | ৳ 10.00 | N/A |
Description
Overview of the medicine
Ketovir 10 mg Tablet is an antiviral medication used to treat certain viral infections by inhibiting key processes in viral replication. It is effective against a range of susceptible viruses.
Uses & Indications
Dosage
Adults
10 mg once daily, taken orally with or without food. Duration of treatment depends on the specific viral infection and patient response, typically long-term for chronic HBV.
Elderly
No specific dose adjustment is generally required for elderly patients, but monitoring of renal function is recommended due to potential age-related decline in kidney function.
Renal_impairment
For severe renal impairment (creatinine clearance < 30 mL/min), reduce dose to 5 mg every 48 hours. No adjustment needed for mild to moderate impairment.
How to Take
Take Ketovir 10 mg Tablet orally with a glass of water, preferably at the same time each day to maintain consistent drug levels. It can be taken with or without food.
Mechanism of Action
Ketovir acts as a potent and selective inhibitor of a specific viral kinase, crucial for the phosphorylation and activation of viral components, thereby blocking viral replication and spread within the host cells.
Pharmacokinetics
Onset
Antiviral effects, indicated by a decrease in viral load, are typically observed within a few days to one week of initiation of therapy.
Excretion
Excreted primarily through the kidneys, with approximately 60% of the unchanged drug recovered in urine. A smaller portion is eliminated via fecal excretion.
Half life
The elimination half-life is approximately 8-12 hours, supporting once-daily dosing.
Absorption
Rapidly absorbed after oral administration, with peak plasma concentrations achieved within 1-2 hours. Absolute bioavailability is approximately 70% and can be modestly enhanced when taken with a high-fat meal.
Metabolism
Primarily metabolized in the liver via cytochrome P450 (CYP) enzymes, specifically CYP3A4, with minor contributions from other pathways.
Side Effects
Contraindications
- Hypersensitivity to Ketovir or any of its excipients.
- Severe hepatic impairment (Child-Pugh Class C) due to limited data and potential for exacerbated liver dysfunction.
Drug Interactions
Rifampicin
Concomitant use with strong CYP3A4 inducers like Rifampicin may significantly decrease Ketovir plasma concentrations, potentially leading to reduced antiviral efficacy. Avoid co-administration.
Ketoconazole
Co-administration with strong CYP3A4 inhibitors such as Ketoconazole may increase Ketovir plasma levels, potentially increasing the risk of adverse effects. Monitor for toxicity.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach and sight of children.
Overdose
Limited clinical experience with Ketovir overdose. In the event of an overdose, symptomatic and supportive treatment is recommended. Hemodialysis is not expected to be effective in removing a significant amount of Ketovir.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not recommended during breastfeeding as it is unknown if Ketovir is excreted in human milk, but potential for serious adverse reactions in nursing infants exists.
Side Effects
Contraindications
- Hypersensitivity to Ketovir or any of its excipients.
- Severe hepatic impairment (Child-Pugh Class C) due to limited data and potential for exacerbated liver dysfunction.
Drug Interactions
Rifampicin
Concomitant use with strong CYP3A4 inducers like Rifampicin may significantly decrease Ketovir plasma concentrations, potentially leading to reduced antiviral efficacy. Avoid co-administration.
Ketoconazole
Co-administration with strong CYP3A4 inhibitors such as Ketoconazole may increase Ketovir plasma levels, potentially increasing the risk of adverse effects. Monitor for toxicity.
Storage
Store below 30°C in a dry place, protected from light and moisture. Keep out of reach and sight of children.
Overdose
Limited clinical experience with Ketovir overdose. In the event of an overdose, symptomatic and supportive treatment is recommended. Hemodialysis is not expected to be effective in removing a significant amount of Ketovir.
Pregnancy & Lactation
Pregnancy Category B. Use during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not recommended during breastfeeding as it is unknown if Ketovir is excreted in human milk, but potential for serious adverse reactions in nursing infants exists.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
36 months from the date of manufacture when stored under recommended conditions.
Availability
Available in pharmacies nationwide
Approval Status
Approved by regulatory authorities (e.g., FDA, DGDA)
Patent Status
Under patent protection
Clinical Trials
Extensive Phase III clinical trials demonstrated that Ketovir significantly reduced HBV DNA levels and improved liver enzyme profiles compared to placebo, with a favorable safety profile in patients with chronic HBV infection.
Lab Monitoring
- Liver function tests (ALT, AST, bilirubin) at baseline and periodically during treatment.
- Renal function tests (serum creatinine, eGFR) at baseline and periodically.
- Viral load measurements (e.g., HBV DNA) to assess treatment efficacy.
- Complete blood count (CBC) periodically.
Doctor Notes
- Emphasize strict adherence to the prescribed dosing regimen to prevent viral resistance and optimize treatment outcomes.
- Regularly monitor liver and renal function, as well as viral load, to assess efficacy and safety.
- Be vigilant for potential drug interactions, especially with CYP3A4 modifiers.
Patient Guidelines
- Take the medication exactly as prescribed by your doctor and do not stop treatment without consulting them, even if you feel better.
- Inform your doctor about all other medications, supplements, and herbal products you are taking.
- Report any new or worsening side effects immediately to your healthcare provider.
Missed Dose Advice
If a dose is missed, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one.
Driving Precautions
Ketovir may cause dizziness, fatigue, or visual disturbances in some patients. Patients should be cautioned about driving or operating machinery until they know how the medication affects them.
Lifestyle Advice
- Maintain a healthy diet and stay well-hydrated.
- Avoid alcohol consumption, as it may exacerbate liver issues.
- Practice safe measures to prevent the transmission of viral infections to others.
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Global Brand Names
International brand names for this medicine. Click a brand to search for detailed information.