Kickof
Generic Name
Dextromethorphan HBr
Manufacturer
Square Pharmaceuticals Ltd.
Country
Bangladesh
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Price Details
Current market pricing information
| Variant | Unit Price | Strip Price |
|---|---|---|
| kickof 15 mg syrup | ৳ 40.00 | N/A |
Description
Overview of the medicine
Kickof 15 mg Syrup is an antitussive medicine used to relieve dry cough by suppressing the cough reflex.
Uses & Indications
Dosage
Adults
15 mg (10 ml) every 4-6 hours as needed, not to exceed 60-120 mg in 24 hours.
Elderly
Similar to adult dosage, but caution advised due to potential for increased sensitivity.
Renal_impairment
No specific dosage adjustment provided, but caution advised.
How to Take
Oral administration. Measure dose with a measuring cup or spoon. May be taken with or without food.
Mechanism of Action
Dextromethorphan acts centrally on the cough center in the medulla to elevate the cough threshold.
Pharmacokinetics
Onset
Onset of action within 15-30 minutes.
Excretion
Excreted primarily via the kidneys as unchanged drug and metabolites.
Half life
Approximately 1.9-5.6 hours (dependent on phenotype).
Absorption
Readily absorbed from the gastrointestinal tract.
Metabolism
Undergoes rapid and extensive hepatic metabolism by cytochrome P450 isoenzymes (primarily CYP2D6).
Side Effects
Contraindications
- •Hypersensitivity to dextromethorphan or any component of the syrup.
- •Concomitant use with MAO inhibitors (or within 14 days of stopping MAO inhibitors).
- •Children under 2 years of age.
Drug Interactions
MAO Inhibitors
Risk of serotonin syndrome (hyperpyrexia, muscle rigidity, mental status changes). Avoid concomitant use.
SSRIs (e.g., fluoxetine, paroxetine)
Increased risk of serotonin syndrome. Monitor for symptoms.
CYP2D6 inhibitors (e.g., quinidine, amiodarone)
Can increase dextromethorphan levels, leading to increased side effects.
Storage
Store below 30°C in a dry place, protected from light. Keep out of reach of children.
Overdose
Symptoms include nausea, vomiting, dizziness, drowsiness, nystagmus, ataxia, CNS depression, respiratory depression. Severe overdose can lead to hallucinations, psychosis, and serotonin syndrome. Treatment is supportive, potentially including activated charcoal and naloxone for severe CNS depression.
Pregnancy & Lactation
Pregnancy Category C. Use only if potential benefit justifies potential risk to the fetus. Consult a doctor. Excreted into breast milk in small amounts; use with caution during lactation.
Frequently Asked Questions
Common questions about this medicine
Pack Sizes
Shelf Life
Typically 24-36 months from manufacturing date.
Availability
Pharmacies nationwide
Approval Status
Approved by DGDA
Patent Status
Generic available
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Global Brand Names
International brand names for this medicine
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